Arousal of cancer-associated stromal fibroblasts: palladin-activated fibroblasts promote tumor invasion.
Arousal of cancer-associated stromal fibroblasts: palladin-activated fibroblasts promote tumor invasion.
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DOI：
10.4161/cam.21453
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发表时间：
2012-11
影响因子：
3.2
通讯作者：
Brentnall TA
中科院分区：
文献类型：
--
作者：
Brentnall TA
癌症相关成纤维细胞（CAF），由活化的成纤维细胞或肌成纤维细胞组成，存在于实体瘤周围的基质中;这些肌成纤维细胞促进癌细胞的侵袭和转移。在肿瘤发生的早期阶段，基质成纤维细胞活化成肌成纤维细胞是由囊骨架蛋白palladin的表达诱导的，并且随着肿瘤进展而增加。palladin在成纤维细胞中的表达是由来自相邻的表达k-ras的上皮细胞的旁分泌信号触发的。表达钯蛋白的成纤维细胞和胰腺癌细胞的三维共培养揭示了活化的成纤维细胞通过穿过细胞外基质创建隧道来引导侵袭，癌细胞通过该隧道跟随。侵袭性隧穿是由于在palladin激活的成纤维细胞中侵袭足样细胞突起的发展和创伤/炎症触发的增加而发生的。去除palladin降低了这些细胞的侵袭能力。CAF还在癌症抗性和免疫豁免中发挥作用，使肿瘤学家感兴趣的这些细胞的激活剂的靶向。
Cancer-associated fibroblasts (CAF), comprised of activated fibroblasts or myofibroblasts, are found in stroma surrounding solid tumors; these myofibroblasts promote invasion and metastasis of cancer cells. Activation of stromal fibroblasts into myofibroblasts is induced by expression of cystoskeleton protein, palladin, at early stages in tumorigenesis and increases with neoplastic progression. Expression of palladin in fibroblasts is triggered by paracrine signaling from adjacent k-ras-expressing epithelial cells. Three-dimensional co-cultures of palladin-expressing fibroblasts and pancreatic cancer cells reveals that the activated fibroblasts lead the invasion by creating tunnels through the extracellular matrix through which the cancer cells follow. Invasive tunneling occurs as a result of the development of invadopodia-like cellular protrusions in the palladin-activated fibroblasts and the addition of a wounding/inflammatory trigger. Abrogation of palladin reduces the invasive capacity of these cells. CAF also play a role in cancer resistance and immuno-privilege, making the targeting of activators of these cells of interest for oncologists.
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影响因子：
8
作者：
Goicoechea, S. M.;Bednarski, B.;Garcia-Mata, R.;Prentice-Dunn, H.;Kim, H. J.;Otey, C. A.
通讯作者：
Otey, C. A.
影响因子：
3.7
作者：
Brentnall TA;Lai LA;Coleman J;Bronner MP;Pan S;Chen R
通讯作者：
Chen R
影响因子：
3.1
作者：
Li X;Ma Q;Xu Q;Duan W;Lei J;Wu E
通讯作者：
Wu E
影响因子：
11.2
作者：
Hwang, Rosa F.;Moore, Todd;Logsdon, Craig D.
通讯作者：
Logsdon, Craig D.
影响因子：
3.7
作者：
Gupta V;Bassi DE;Simons JD;Devarajan K;Al-Saleem T;Uzzo RG;Cukierman E
通讯作者：
Cukierman E