Prevalence of mild cognitive impairment in an urban community in China: A cross-sectional analysis of the Shanghai Aging Study
Prevalence of mild cognitive impairment in an urban community in China: A cross-sectional analysis of the Shanghai Aging Study
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DOI：
10.1016/j.jalz.2013.11.002
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发表时间：
2015-03-01
影响因子：
14
通讯作者：
Hong, Zhen
中科院分区：
文献类型：
--
作者：
Ding, Ding;Zhao, Qianhua;Hong, Zhen
背景：据报道，轻度认知损害(MCI)的患病率有很大的差异，尽管主要发生在西方国家。中国人对MCI知之甚少。方法：我们对3141名60岁的社区居民进行临床和神经心理学评估。结果：2985例非痴呆患者中，601例确诊为MCI，占总MCI的20.1%，遗忘性MCI(AMCI)13.2%，非遗忘性MCI(NAMCI)7.0%。MCI亚型构成比为：aMCI单域(SD)占38.9%，aMCI多域(MD)占26.5%，NAMCI-SD占25.0%，NAMCI-MD占9.6%。女性APOE携带者aMCI-MD的患病率随着年龄的增长而迅速增加(60~69岁=80岁，3.1%~33.3%，P<；001)。结论：我们的研究结果提示中国老年人中有20%的人患有MCI。中国的前瞻性研究需要检查进展为痴呆症和相关的危险因素。(C)2015年阿尔茨海默氏症协会。爱思唯尔公司出版，版权所有。
Background: Substantial variations in the prevalence of mild cognitive impairment (MCI) have been reported, although mostly in Western countries. Less is known about MCI in the Chinese population.Methods: We clinically and neuropsychologically evaluated 3141 community residents >= 60 years of age. Diagnoses of MCI and its subtypes were made using standard criteria via consensus diagnosis.Results: Among 2985 nondemented individuals, 601 were diagnosed with MCI, resulting in a prevalence of 20.1% for total MCI, 13.2% for amnestic MCI (aMCI), and 7.0% for non-amnestic MCI (naMCI). The proportions of MCI subtypes were: aMCI single domain (SD), 38.9%; aMCI multiple domains (MD), 26.5%; naMCI-SD, 25.0%; and naMCI-MD, 9.6%. The prevalence of aMCI-MD increased rapidly with age in women APOE 64 carriers (from 60 to 69 years to >= 80 years, 3.1%-33.3%, P < .001).Conclusions: Our findings suggest that 20% of Chinese elderly are affected by MCI. Prospective studies in China are needed to examine progression to dementia and related risk factors. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.