Sex-associated differences in the antibody-dependent cellular cytotoxicity antibody response to measles vaccines
Sex-associated differences in the antibody-dependent cellular cytotoxicity antibody response to measles vaccines
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DOI：
10.1128/cdli.7.1.111-113.2000
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发表时间：
2000-01-01
期刊：
影响因子：
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通讯作者：
Forthal, DN
中科院分区：
文献类型：
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作者：
Atabani, S;Landucci, G;Forthal, DN
在一些国家，在接种高滴度麻疹疫苗的女性中观察到非麻疹相关死亡率过高。我们确定是否在麻疹疫苗的免疫反应的差异的基础上过度的女性死亡率，通过测量麻疹病毒（MV）特异性抗体依赖性细胞毒性（ADCC）抗体反应在65 3岁的冈比亚儿童接种埃德蒙顿-萨格勒布中滴度（EZ）或施瓦茨标准疫苗在婴儿期。在免疫时检测不到抗MV抗体的20名女性和22名男性中，女性的ADCC显著低于男性（1/100血清稀释度的中位细胞毒性分别为8.4和12%; P = 0.04）。这种性别相关的差异仅存在于EZ疫苗的6名女性和7名男性接受者中（中位细胞毒性分别为5.1%和19.0%; P = 0.02）。中和抗体活性无显著性别相关差异。ADCC抗体活性降低可能导致接受高滴度麻疹疫苗接种的女性存活率降低。
In some countries, excessive non-measles-related mortality has been observed among female recipients of high-titer measles vaccines. We determined if differences in the immune response to measles vaccines underlie the excessive female mortality by measuring the measles virus (MV)-specific antibody-dependent cellular cytotoxicity (ADCC) antibody response in 65 3-year-old Gambian children immunized with Edmonston-Zagreb medium-titer (EZ) or Schwarz standard vaccines during infancy. Among the 20 females and 22 males with undetectable anti-MV antibodies at the time of immunization, females had significantly lower ADCC than males (median cytotoxicities of 1/100 serum dilutions = 8.4 and 12%, respectively; P = 0.04). This sex-associated difference was present only among the six female and seven male recipients of EZ vaccine (median cytotoxicities = 5.1 and 19.0%, respectively; P = 0.02). There were no significant sex-associated differences in neutralizing antibody activity. Decreased ADCC antibody activity may contribute to the lower survival rate observed in females receiving high-titer measles vaccination.