TRANSMISSION OF BOVINE SPONGIFORM ENCEPHALOPATHY AND SCRAPIE TO MICE - STRAIN VARIATION AND THE SPECIES BARRIER
TRANSMISSION OF BOVINE SPONGIFORM ENCEPHALOPATHY AND SCRAPIE TO MICE - STRAIN VARIATION AND THE SPECIES BARRIER
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DOI：
10.1098/rstb.1994.0036
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发表时间：
1994-03-29
影响因子：
6.3
通讯作者：
FRASER, H
中科院分区：
文献类型：
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作者：
BRUCE, M;CHREE, A;FRASER, H
从7个不相关的牛来源传播的牛海绵状脑病(BSE)在小鼠身上表现出非常一致的疾病特征，不同于以前和当代20多种绵羊和山羊瘙痒病的传播。通过实验或自然感染疯牛病的六种动物(包括绵羊和山羊)向小鼠传播海绵状脑病的结果与牛直接传播疯牛病的结果相似。因此，BSE试剂在通过一系列物种时保持了其身份，而“供体”物种对小鼠的疾病特征几乎没有具体影响，这增加了试剂特异性信息分子的证据。在将疯牛病或瘙痒病传播给小鼠时，与随后的小鼠对小鼠的传代相比，潜伏期较长(“物种障碍”)。致病因素包括感染对物种间传播的效率低，大脑内注射的外来接种明显未能直接在小鼠脑内建立感染，以及选择在新宿主物种中最容易复制的变种毒剂。
Transmissions of bovine spongiform encephalopathy (BSE) from seven unrelated cattle sources have given remarkably uniform disease characteristics in mice, differing from over twenty previous and contemporary transmissions of sheep and goat scrapie. Transmissions to mice of spongiform encephalopathy from six species (including sheep and goats) which have been experimentally or naturally infected with BSE have given similar results to direct BSE transmissions from cattle. Therefore the BSE agent has retained its identity when passaged through a range of species and the 'donor' species has little specific influence on disease characteristics in mice, adding to evidence for an agent-specific informational molecule. On transmission of BSE or scrapie to mice the incubation periods are long compared with subsequent mouse-to-mouse passages (the 'species barrier'). Contributing factors include a low efficiency of infection on interspecies transmission, the apparent failure of intracerebrally injected 'foreign inoculum to establish infection directly in mouse brain and the selection of variant strains of agent which replicate most readily in the new host species.