Association between epidermal growth factor 61A/G polymorphism and hepatocellular carcinoma susceptibility in Chinese patients
Association between epidermal growth factor 61A/G polymorphism and hepatocellular carcinoma susceptibility in Chinese patients
复制标题
表皮生长因子61A/G多态性与中国患者肝癌易感性的关系
DOI：
10.1111/j.1478-3231.2009.02134.x
复制
发表时间：
2010-01-01
影响因子：
6.7
通讯作者：
Zhuang, Hui
中科院分区：
文献类型：
--
作者：
Li, Yajuan;Xie, Qing;Zhuang, Hui
背景与目的：慢性乙型肝炎病毒感染是中国地区肝细胞癌发生的重要危险因素，但对其发生的遗传易感性却知之甚少。表皮生长因子(EGF)途径在包括肝细胞癌在内的肿瘤发生中起重要作用。EGF基因多态与多种癌症的易感性有关。因此，本研究旨在评估EGF基因多态性是否会影响肝细胞癌的发生。
Background and aims: Chronic hepatitis B virus (HBV) infection is an important risk factor for hepatocellular carcinoma (HCC) development in China, while little is known of the genetic susceptibility to hepatocarcinogenesis. The epidermal growth factor (EGF) pathway plays an important role in tumorigenesis, including HCC. EGF polymorphisms are associated with susceptibility to several types of cancers. Therefore, this study aimed to assess whether EGF genetic polymorphisms can influence HCC development.