Microwave-assisted synthesis in aqueous medium of new quinazoline derivatives as anticancer agent precursors
Microwave-assisted synthesis in aqueous medium of new quinazoline derivatives as anticancer agent precursors
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DOI：
10.1039/b816723k
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发表时间：
2009-01-01
期刊：
影响因子：
9.8
通讯作者：
Vanelle, P.
中科院分区：
文献类型：
--
作者：
Kabri, Y.;Gellis, A.;Vanelle, P.
本文报道了在微波辐射下，由2-氯甲基-3-甲基喹唑啉-4（3 H）-酮衍生物与不同的苯亚磺酸和硝酸根阴离子通过S-烷基化或S（RN）1反应快速、环保地“绿色绿色合成”新的2-取代喹唑啉衍生物。
Fast and eco-friendly microwave-irradiated reactions permitting the "green synthesis" of new 2-substituted quinazoline derivatives in aqueous medium via S-alkylation or S(RN)1 reaction from 2-chloromethyl-3-methylquinazolin-4(3H)-one derivatives with different benzenesulfinic acids and nitronate anions, are reported herein.