Association between beta-blockers and fracture risk: a Bayesian meta-analysis.
Association between beta-blockers and fracture risk: a Bayesian meta-analysis.
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DOI：
10.1016/j.bone.2012.07.013
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发表时间：
2012-11
期刊：
影响因子：
4.1
通讯作者：
Shuman Yang;N. Nguyen;J. Eisman;Tuan V. Nguyen
中科院分区：
文献类型：
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作者：
Shuman Yang;N. Nguyen;J. Eisman;Tuan V. Nguyen
背景β受体阻滞剂（BB）与骨折风险之间的关联存在争议，这主要是由于先前研究的结果相互矛盾。本研究试图通过贝叶斯荟萃分析方法来评估 BB 对骨折风险的影响。方法和结果我们系统地检索了 13 项关于 BB 使用与骨折风险之间关系的观察性研究。这项荟萃分析涉及超过 907,000 名男性和女性，个别研究的平均/中位年龄为 43 至 81 岁。我们使用分层贝叶斯随机效应模型来综合结果。使用 BB 可使任何骨折（风险比 [RR] 0.83；95% 可信区间 [CrI]：0.71–0.93）、髋部骨折（RR 0.83；95% CrI：0.70–0.92）和椎骨骨折（RR 0.81；95% CrI：0.61–0.99）的风险平均降低 17%。使用 BB 可使骨折风险至少降低 10% 的概率为 0.91。结论 β 受体阻滞剂与老年人骨折风险降低相关，但效果可能不大。
BACKGROUNDThe association between beta-blockers (BB) and fracture risk is controversial, due largely to conflicting findings from previous studies. The present study sought to evaluate the effect of BB on fracture risk by using a Bayesian meta-analysis approach.METHODS AND RESULTSWe systematically retrieved 13 observational studies on the association between BB use and fracture risk. This meta-analysis involved more than 907,000 men and women with mean/median age of individual studies ranging from 43 to 81years. We used a hierarchical Bayesian random effects model to synthesize the results. BB use was associated with an average 17% reduction in the risk of any fracture (risk ratio [RR] 0.83; 95% credible interval [CrI]: 0.71–0.93), hip fracture (RR 0.83; 95% CrI: 0.70–0.92) and vertebral fracture (RR 0.81; 95% CrI: 0.61–0.99). The probability that BB use reduces fracture risk by at least 10% was 0.91.CONCLUSIONSBeta-blockers are associated with reduced risk of fracture in older adults, but the effect size is likely to be modest.