The cation channel TRPA1 tunes mosquito thermotaxis to host temperatures
The cation channel TRPA1 tunes mosquito thermotaxis to host temperatures
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DOI：
10.7554/elife.11751
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发表时间：
2015-12-15
期刊：
影响因子：
7.7
通讯作者：
Vosshall, Leslie B.
中科院分区：
文献类型：
--
作者：
Corfas, Roman A.;Vosshall, Leslie B.
虽然大多数动物只是为了调节自己的体温，但雌性蚊子在追求血食时会被人体的热量所吸引。在这里，我们阐明了埃及伊蚊趋热性的基本规则，并测试候选温度感受器在这一重要行为中的功能。我们发现，寻求宿主的蚊子最大限度地吸引接近宿主体温的热刺激，寻求相对温暖，同时避免相对凉爽和刺激超过宿主体温。我们发现，阳离子通道TRPA 1，除了发挥保守的作用，在体温调节和化学感觉，是需要这种专门的主机选择性趋热性蚊子。在寻找寄主过程中，AaegTRPA 1（-/-）突变体不能避免超过寄主温度的刺激，并且不能区分寄主温度和高温刺激。TRPA 1依赖的趋热性调节可能是蚊子在复杂的热环境中寻找宿主的关键，在这种热环境中，人类比环境空气温暖，但比周围阳光温暖的表面凉爽。
While most animals thermotax only to regulate their temperature, female mosquitoes are attracted to human body heat during pursuit of a blood meal. Here we elucidate the basic rules of Aedes aegypti thermotaxis and test the function of candidate thermoreceptors in this important behavior. We show that host-seeking mosquitoes are maximally attracted to thermal stimuli approximating host body temperatures, seeking relative warmth while avoiding both relative cool and stimuli exceeding host body temperature. We found that the cation channel TRPA1, in addition to playing a conserved role in thermoregulation and chemosensation, is required for this specialized host-selective thermotaxis in mosquitoes. During host-seeking, AaegTRPA1(-/-) mutants failed to avoid stimuli exceeding host temperature, and were unable to discriminate between host-temperature and high-temperature stimuli. TRPA1-dependent tuning of thermotaxis is likely critical for mosquitoes host-seeking in a complex thermal environment in which humans are warmer than ambient air, but cooler than surrounding sun-warmed surfaces.