Zinc deficiency in elderly patients.
Zinc deficiency in elderly patients.
复制标题
DOI：
--
复制
发表时间：
1993-05
期刊：
影响因子：
4.4
通讯作者：
A. Prasad;J. Fitzgerald;J. W. Hess;J. Kaplan;F. Pelen;M. Dardenne
中科院分区：
文献类型：
--
作者：
A. Prasad;J. Fitzgerald;J. W. Hess;J. Kaplan;F. Pelen;M. Dardenne
锌是生长发育、DNA合成、神经感觉功能和细胞免疫所必需的。虽然老年人的锌摄入量减少，但锌的缺乏及其对老年人细胞免疫的影响尚未确定。对参加“美国城市中老年人健康促进和干预示范计划”的受试者进行了营养和锌营养状况评估。180名健康受试者被随机选为研究对象。他们的平均膳食锌摄入量为9.06毫克/天，而推荐的膳食摄入量为15毫克/天。与年轻对照组相比，血浆锌正常，但粒细胞和淋巴细胞锌降低。在118名粒细胞和淋巴细胞锌水平均可获得的老年受试者中，36人锌水平不足。血浆铜明显升高，白介素1(IL-1)生成明显减少。观察到对皮肤测试抗原板的反应降低，味觉敏锐度降低。对13名缺锌老年受试者进行了补锌，并对补锌前后的各项变量进行了评估。补锌可纠正缺锌，使血浆铜水平正常化。补充后血清胸腺激素活性、IL-1产量和淋巴细胞胞外5‘-核苷酸酶均显著提高。在补充锌后，观察到对皮肤试验抗原的反应和味觉的改善。轻度缺锌似乎是自由生活老年人的一个重大临床问题。
Zinc is needed for growth and development, DNA synthesis, neurosensory functions, and cell-mediated immunity. Although zinc intake is reduced in elderly people, its deficiency and effects on cell-mediated immunity of the elderly have not been established. Subjects enrolled in "A Model Health Promotion and Intervention Program for Urban Middle Aged and Elderly Americans" were assessed for nutrition and zinc status. One hundred eighty healthy subjects were randomly selected for the study. Their mean dietary zinc intake was 9.06 mg/day, whereas the recommended dietary allowance is 15 mg/day. Plasma zinc was normal, but zinc in granulocytes and lymphocytes were decreased compared with younger control subjects. Of 118 elderly subjects in whom zinc levels in both granulocytes and lymphocytes were available, 36 had deficient levels. Plasma copper was increased, and interleukin 1 (IL-1) production was significantly decreased. Reduced response to the skin-test antigen panel and decreased taste acuity were observed. Thirteen elderly zinc-deficient subjects were supplemented with zinc, and various variables were assessed before and after zinc supplementation. Zinc supplementation corrected zinc deficiency and normalized plasma copper levels. Serum thymulin activity, IL-1 production, and lymphocyte ecto-5'-nucleotidase increased significantly after supplementation. Improvement in response to skin-test antigens and taste acuity was observed after zinc supplementation. A mild zinc deficiency appears to be a significant clinical problem in free-living elderly people.