Extracorporeal photopheresis for the treatment of Sezary syndrome using a novel treatment protocol
Extracorporeal photopheresis for the treatment of Sezary syndrome using a novel treatment protocol
复制标题
DOI：
10.1016/j.jaad.2008.05.038
复制
发表时间：
2008-10-01
影响因子：
13.8
通讯作者：
McCormack, Christopher
中科院分区：
文献类型：
--
作者：
Arulogun, Suzanne;Prince, H. Miles;McCormack, Christopher
各种研究报告称，体外光采术可以有效地为塞扎里综合征患者产生有意义的反应。我们对接受体外光采术的 Sezary 综合征患者进行了一项单中心 5 年回顾性分析。 13 名患者持续接受体外光采术治疗至少 2 个月。所有患者均接受修改方案，每周一次治疗，持续 6 个疗程，每 2 周一次治疗，持续 6 个疗程，然后每月一次。总体缓解率为 62%，2 名患者实现完全缓解，6 名患者实现部分缓解。中位反应时间为 10 个月。 2 年和 4 年预测总生存率为 82%。这项研究因其回顾性和样本量小而受到限制。与之前的研究相比，反应率和生存率都不错。我们修改后的治疗方案似乎产生了与两天方案类似的结果。
Various studies have reported that extracorporal photopheresis is effective in producing meaningful responses in patients with Sezary syndrome. A single-center, 5-year retrospective analysis was performed on our patients with Sezary syndrome who received extracorporeal photopheresis using a novel protocol. Thirteen patients were treated with extracorporeal photopheresis consistently for a minimum of 2 months. All patients received a modified protocol of one treatment per week for 6 sessions, one session every 2 weeks for 6 sessions, and then one session per month. The overall response rate was 62% two patients achieved a complete response and 6 patients achieved a partial response. The median time to response was 10 months. The 2- and 4-year predicted overall survivals were 82%. This study was limited by its retrospective nature and small sample size. Response and survival compare favorably with those of previous studies. Our modified treatment protocol appears to produce outcomes similar to the two-day protocol.