LINKAGE BETWEEN SEXUAL ORIENTATION AND CHROMOSOME XQ28 IN MALES BUT NOT IN FEMALES
LINKAGE BETWEEN SEXUAL ORIENTATION AND CHROMOSOME XQ28 IN MALES BUT NOT IN FEMALES
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DOI：
10.1038/ng1195-248
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发表时间：
1995-11-01
期刊：
影响因子：
30.8
通讯作者：
HAMER, DH
中科院分区：
文献类型：
--
作者：
HU, S;PATTATUCCI, AML;HAMER, DH
我们已经扩展了我们的分析的作用，长臂的X染色体（Xq28）在性取向的DNA连锁分析的两个新确定的一系列家庭，包含两个同性恋兄弟或两个同性恋姐妹篇以及异性恋兄弟姐妹。在男同性恋家庭中检测到Xq28标记和性取向之间的联系，但在女同性恋家庭或未能满足性连锁性取向研究的定义纳入标准的家庭中没有检测到。我们的结果证实了之前报道的Xq 28与选定亲属中男性同性恋之间的联系，并表明该区域包含一个影响男性性取向个体差异的基因座，但不影响女性性取向的个体差异。
We have extended our analysis of the role of the long arm of the X chromosome (Xq28) in sexual orientation by DNA linkage analyses of two newly ascertained series of families that contained either two gay brothers or two lesbian sisters as well as heterosexual siblings. Linkage between the Xq28 markers and sexual orientation was detected for the gay male families but not for the lesbian families or for families that failed to meet defined inclusion criteria for the study of sex-linked sexual orientation. Our results corroborate the previously reported linkage between Xq28 and male homosexuality in selected kinships and suggest that this region contains a locus that influences individual variations in sexual orientation in men but not in women.