Molecular mechanisms of midfacial developmental defects.
Molecular mechanisms of midfacial developmental defects.
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DOI：
10.1002/dvdy.24368
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发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Iwata J
中科院分区：
文献类型：
--
作者：
Suzuki A;Sangani DR;Ansari A;Iwata J
The morphogenesis of midfacial processes requires the coordination of a variety of cellular functions of both mesenchymal and epithelial cells to develop complex structures. Any failure or delay in midfacial development as well as any abnormal fusion of the medial and lateral nasal and maxillary prominences will result in developmental defects in the midface with a varying degree of severity, including cleft, hypoplasia, and midline expansion. In spite of the advances in human genome sequencing technology, the causes of nearly 70 percent of all birth defects, which include midfacial development defects, remain unknown. Recent studies in animal models have highlighted the importance of specific signaling cascades and genetic-environmental interactions in the development of the midfacial region. This review will summarize the current understanding of the morphogenetic processes and molecular mechanisms underlying midfacial birth defects based on mouse models with midfacial developmental abnormalities.
