Functional insights into aberrant brain responses and integration in patients with lifelong premature ejaculation.
Functional insights into aberrant brain responses and integration in patients with lifelong premature ejaculation.
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对终生早泄患者异常大脑反应和整合的功能见解
DOI：
10.1038/s41598-017-00421-3
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发表时间：
2017-03-28
影响因子：
4.6
通讯作者：
Dai Y
中科院分区：
文献类型：
--
作者：
Zhang B;Lu J;Xia J;Wang F;Li W;Chen F;Han Y;Chen Y;Zhu B;Qing Z;Zhang X;Dai Y
尽管终身早泄（PE）非常普遍，但很少有研究调查其背后的神经机制。大脑激活的程度和模式可以通过功能磁共振成像（fMRI）与情色图片刺激（任务fMRI）和静息状态fMRI （rs fMRI）来确定。我们发现，在任务和静息状态下，大脑左侧额下回和左脑岛的活动都减少了，而在任务期间，右侧颞中回的活动增加了。这三个脑区与双侧中扣带皮层、右侧额叶中回和辅助运动区之间的功能连通性较高。此外，脑活动与临床评定量表如阴道内射精潜伏期（IELT）和中国早泄指数（CIPE）有正相关。这些发现表明，在PE病例中，大脑反应和某些大脑区域的功能整合受到损害，这得到了使用任务和rs fMRI方法获得的多次测量结果的一致支持。
Even though lifelong premature ejaculation (PE) is highly prevalent, few studies have investigated the neural mechanisms underlying PE. The extent and pattern of brain activation can be determined through a version of functional magnetic resonance imaging (fMRI) with erotic picture stimuli (task fMRI) and a resting-state fMRI (rs fMRI). We showed that the brain activity in the left inferior frontal gyrus and left insula was decreased both during the task and in the resting state, while there was higher activation in the right middle temporal gyrus during the task. Higher functional connectivity was found in PE between those three brain areas and the bilateral middle cingulate cortex, right middle frontal gyrus and supplementary motor area. Moreover, the brain activity had positive correlation with clinical rating scales, such as intravaginal ejaculatory latency time (IELT) and the Chinese Index of Premature Ejaculation (CIPE). These findings revealed that brain responses and functional integration in certain brain areas are impaired in cases of PE, which was consistently supported by multiple measurements obtained using a task and rs fMRI approach.