A prognostic index for colorectal cancer based on preoperative absolute lymphocyte, monocyte, and neutrophil counts
A prognostic index for colorectal cancer based on preoperative absolute lymphocyte, monocyte, and neutrophil counts
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DOI：
10.1007/s00595-018-1728-6
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发表时间：
2018-10
期刊：
影响因子：
2.5
通讯作者：
Akimitsu Tanio;H. Saito;Chihiro Uejima;S. Takaya;Manabu Yamamoto;Naruo Tokuyasu;Teruhisa Sakamoto;S. Honjo;K. Ashida;Y. Fujiwara
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作者：
Akimitsu Tanio;H. Saito;Chihiro Uejima;S. Takaya;Manabu Yamamoto;Naruo Tokuyasu;Teruhisa Sakamoto;S. Honjo;K. Ashida;Y. Fujiwara
结直肠癌（CRC）患者术前外周血中性粒细胞绝对计数（NC）、淋巴细胞计数（LC）和单核细胞计数（MC）与预后的相关性尚未得到广泛研究。方法我们纳入了2007年1月至2013年12月期间接受手术治疗的361例CRC患者，分析LC、MC、MC与预后的相关性。结果根据受试者操作特征分析确定的截止值，将患者亚组为LymphHigh或LymphLow（截止值：LC = 1460个细胞/μL）; MonoHigh或MonoLow（截止值：MC = 421个细胞/μL）; NeutHigh或NeutLow（截止值：NC = 3247个细胞/μL）。然后通过将患者不同亚组的分数相加（LymphLow、MonoHigh和NeutHigh各1分; LymphHigh、MonoLow和NeutLow为0分），对患者进行淋巴细胞-单核细胞-中性粒细胞（LMN）评分。5年总生存率随LMN评分的不同而有显著性差异（0：89.7%，1：80.6%，2：68.8%，3：57.4%，P< 0.0001）。在多变量分析中，LMN评分被发现是一个独立的预后indicator.ConclusionsThe术前淋巴细胞，单核细胞和中性粒细胞的绝对数量的组合是一个有用的预后指标在CRC患者。
PurposeAssociations between the preoperative absolute neutrophil count (NC), lymphocyte count (LC), and monocyte count (MC) in the peripheral blood and the prognosis of colorectal cancer (CRC) patients have not been widely studied.MethodsWe enrolled 361 patients who underwent surgery for CRC between January 2007 and December 2013 to analyze correlations among the LC, MC, and NC and prognosis.ResultsBased on cut-off values determined by a receiver operating characteristic analysis, patients were subgrouped as LymphHighor LymphLow(cut-off: LC = 1460 cells/µL); as MonoHighor MonoLow(cut-off: MC = 421 cells/µL); and as NeutHighor NeutLow(cut-off: NC = 3247 cells/µL). Patients were then given lymphocyte–monocyte–neutrophil (LMN) scores by adding the points of their different subgroups (1 point each for LymphLow, MonoHighand NeutHigh; 0 points for LymphHigh, MonoLowand NeutLow). The 5-year overall survival rates significantly differed by the LMN score (0: 89.7%, 1: 80.6%, 2: 68.8%, and 3: 57.4%;P< 0.0001). In the multivariate analysis, the LMN score was found to be an independent prognostic indicator.ConclusionsThe combination of the preoperative absolute number of lymphocytes, monocytes, and neutrophils is a useful prognostic indicator in CRC patients.