Effects of dietary modification with weight loss on central blood pressure during oral glucose tolerance test in overweight/obese men.
Effects of dietary modification with weight loss on central blood pressure during oral glucose tolerance test in overweight/obese men.
复制标题
减肥饮食调整对超重/肥胖男性口服葡萄糖耐量试验期间中心血压的影响。
DOI：
10.1016/j.artres.2017.10.199
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发表时间：
2017
期刊：
影响因子：
0.6
通讯作者：
Maeda S.
中科院分区：
文献类型：
--
作者：
Yoshikawa T;Kumagai H;Myoenzono K;Zempo-Miyaki A;Tsujimoto T;Tanaka K;Maeda S.
餐后中枢收缩压（cSBP）的调节受到肥胖相关疾病的损害。本研究旨在探讨低热量饮食干预对超重/肥胖男性口服葡萄糖耐量试验（OGTT）时cSBP的影响，并探讨其机制。方法15名超重/肥胖男性（平均±SD，年龄52±10岁，体重指数29.1±2.3 kg/ m2）完成了为期12周的饮食改变计划（12周内进行8次小组讲座和个人咨询，1680 kcal/天）。在计划前后，测量体重、每日总能量和主要常量营养素摄入量、血脂和胰岛素抵抗的稳态模型评估（HOMA-IR），并在空腹和75 g口服葡萄糖负荷后60分钟和120分钟评估血浆葡萄糖、血清胰岛素和cSBP（即径向第二收缩压）。结果为期12周的减肥计划成功减轻了体重（- 10.1 kg或- 12.1%），并显著减少了每日总能量和主要宏量营养素的摄入量。因此，OGTT期间的低密度脂蛋白胆固醇、甘油三酯、HOMA-IR（2.1±1.3至0.8±0.3,p< 0.01）、葡萄糖和胰岛素在12周后显著降低。饮食计划也导致OGTT期间2小时平均cSBP显著降低（111±11至103±10 mmHg，p< 0.01）。HOMA-IR与2小时平均cSBP与基线变化有显著相关性（rs= 0.69,p< 0.01）。结论：目前的研究结果表明，饮食改变引起的胰岛素抵抗的改善有助于超重/肥胖男性在OGTT期间显著降低cSBP。
BackgroundPostprandial regulation of central systolic blood pressure (cSBP) is impaired by obesity-related disorders. The present study aimed to examine the effect of hypocaloric diet intervention on cSBP when performing oral glucose tolerance test (OGTT) in overweight/obese men and explore its mechanism.MethodsFifteen overweight/obese men (mean ± SD; age, 52 ± 10 years; BMI, 29.1 ± 2.3 kg/ m2) completed a 12-week dietary modification program (group lectures and individual counseling conducted 8 times in 12 weeks, 1680 kcal/day). Before and after the program, body mass, daily intakes of total energy and major macronutrients, serum lipid profiles, and homeostasis model assessment for insulin resistance (HOMA-IR) were measured, and plasma glucose, serum insulin, and cSBP (i.e., radial second systolic pressure) were assessed when fasting and at 60 min and 120 min after 75 g oral glucose loading.ResultsThe 12-week program led to successful weight loss (−10.1 kg or −12.1%) with significant reductions in the daily intakes of total energy and major macronutrients. Consequently, low-density lipoprotein cholesterol, triglycerides, HOMA-IR (2.1 ± 1.3 to 0.8 ± 0.3,p< 0.01), and glucose and insulin during OGTT were substantially decreased after 12 weeks. The diet program had also resulted in significantly reduced 2-h averaged cSBP during OGTT (111 ± 11 to 103 ± 10 mmHg,p< 0.01). There was a significant correlation between the changes from baseline in both HOMA-IR and 2-h averaged cSBP (rs= 0.69,p< 0.01).ConclusionsThe current results suggest that the dietary modification—induced improvement in insulin resistance has contributed to a significant reduction in cSBP during OGTT in overweight/obese men.