Phaeosphaerins A-F, Cytotoxic Perylenequinones from an Endolichenic Fungus, Phaeosphaeria sp.
Phaeosphaerins A-F, Cytotoxic Perylenequinones from an Endolichenic Fungus, Phaeosphaeria sp.
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DOI：
10.1021/np200614h
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发表时间：
2012-02-01
影响因子：
5.1
通讯作者：
Lou, Hongxiang
中科院分区：
文献类型：
--
作者：
Li, Gang;Wang, Haiying;Lou, Hongxiang
从一种内生真菌Phaeosphaeria sp.中分离得到6个新的光毒素phaeosphaerins A-F（1-6）和6个已知的苝醌类化合物，经MS、NMR和电子圆二色性计算确定了它们的结构。这些毒素在体外杀死癌细胞，在溶酶体中积累，并且在光的存在下有效地增强了杀伤作用。
Six novel phototoxins, phaeosphaerins A-F (1-6), together with six known perylenequinones were isolated from an endolichenic fungus Phaeosphaeria sp. Their structures were determined unequivocally on the basis of comprehensive analysis of MS and NMR data as well as electronic circular dichroism calculations. These toxins kill cancer cells in vitro with accumulation in lysosomes, and the killing effects were potently intensified in the presence of light.