The effect of dorsal cochlear nucleus ablation on tinnitus in rats
The effect of dorsal cochlear nucleus ablation on tinnitus in rats
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DOI：
10.1016/j.heares.2004.12.013
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发表时间：
2005-08-01
期刊：
影响因子：
2.8
通讯作者：
Bauer, CA
中科院分区：
文献类型：
--
作者：
Brozoski, TJ;Bauer, CA
越来越多的证据表明，耳蜗背核 (DCN) 在耳鸣中发挥着重要作用。为了检验 DCN 的头侧输出对于慢性耳鸣的体验是必要的这一假设，具有耳鸣心理物理证据的大鼠的背侧 DCN 和背侧声纹被消融。如果 DCN 在慢性耳鸣的产生中起着必要的作用，那么消融 DCN 应该会减少先前显示患有耳鸣的受试者的耳鸣证据。与预测相反，双侧背侧 DCN 消融并没有显着（n = 11，p = 0.707）影响耳鸣的心理物理证据，与消融前的表现相比，同侧背侧 DCN 消融似乎增加了耳鸣的证据（n = 9，p = 0.018）。结论是 DCN 并不是慢性耳鸣的简单前馈源。考虑了其他假设，其中声损伤后 DCN 活动升高会触发分布在听觉系统多个层面的持续病理变化。除了充当触发器之外，DCN 还可以改变耳鸣的体验，因为同侧 DCN 消融增强了耳鸣的证据。 (c) 2005 Elsevier B.V. 保留所有权利。
A growing body of evidence implies that the dorsal cochlear nucleus (DCN) plays an important role in tinnitus. To test the hypothesis that the rostral Output of the DCN is necessary for the experience of chronic tinnitus, the dorsal DCN and the dorsal acoustic stria of rats with psychophysical evidence of tinnitus was ablated. If the DCN plays a necessary role in the generation of chronic tinnitus, ablating the DCN should decrease the evidence of tinnitus in subjects previously shown to have tinnitus. Contrary to prediction, bilateral dorsal DCN ablation did not significantly (n = 11, p = 0.707) affect the psychophysical evidence of tinnitus, and ipsilateral dorsal DCN ablation appeared to increase the evidence of tinnitus (n = 9, p = 0.018) compared to pre-ablation performance. It was concluded that the DCN does not act as a simple feed-forward source of chronic tinnitus. Alternative hypotheses were considered, among them that elevated DCN activity following acoustic trauma triggers persistent pathological changes distributed across more than one level of the auditory system. In addition to serving as a trigger, the DCN may also modify the experience of tinnitus, since the evidence of tinnitus was enhanced by ipsilateral DCN ablation. (c) 2005 Elsevier B.V. All rights reserved.