TUMORIGENICITY OF CITRININ IN MALE F344 RATS
TUMORIGENICITY OF CITRININ IN MALE F344 RATS
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DOI：
10.1016/0304-3835(83)90165-9
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发表时间：
1983-01-01
期刊：
影响因子：
9.7
通讯作者：
HIBINO, T
中科院分区：
文献类型：
--
作者：
ARAI, M;HIBINO, T
报道了桔霉素的致瘤性。雄性F344大鼠饲喂含0.1%桔霉素的饲料80周。在第52周处死的接受桔霉素的大鼠中肉眼观察到第1个肾肿瘤。40周后存活的48只大鼠中，35只（72.9%）的肾脏组织学显示肾腺瘤。在对照组大鼠中未观察到肾肿瘤。
The tumorigenicity of citrinin, a nephrotoxic mycotoxin, is reported. Male F344 rats were fed 0.1% citrinin in the diet for up to 80 wk. The 1st renal tumor was seen grossly in a rat receiving citrinin which was killed at wk 52. Histopathology of the kidneys showed renal adenomas in 35 of 48 (72.9%) rats that survived after 40 wk. No renal tumors were seen in the control rats.