Development of an N-heterocyclic carbene ligand based on concept of chiral mimetic
Development of an N-heterocyclic carbene ligand based on concept of chiral mimetic
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DOI：
10.1016/j.tetlet.2005.12.098
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发表时间：
2006-02-27
影响因子：
1.8
通讯作者：
Aoyama, T
中科院分区：
文献类型：
--
作者：
Arao, T;Kondo, K;Aoyama, T
基于手性模拟物的概念，发展了一种新的N-杂环卡宾配体。在Pd催化的N-（2-溴苯基）-N-甲基-2-芳基丙酰胺的对映选择性分子内α-芳基化反应中，（4 R，5 R）-4，5-二苯基-1，3-二金刚烷基甲基-4，5-二氢-3H-咪唑-1-鎓四氟硼酸盐显示出作为良好的N-杂环卡宾前体的功能。(c)2005爱思唯尔有限公司保留所有权利。
Development of a new N-heterocyclic carbene ligand based on the concept of a chiral mimetic is described. In Pd-catalyzed enantioselective intramolecular alpha-arylation of N-(2-bromophenyl)-N-methyl-2-arylpropanamide, (4R,5R)-4,5-diphenyl-l,3diadamantylmethyl-4,5-dihydro-3H-imidazol-1-ium tetrafluoroborate is shown to function as a good N-heterocyclic carbene precursor. (c) 2005 Elsevier Ltd. All rights reserved.