n-3 Polyunsaturated fatty acids and human cytokine synthesis
n-3 Polyunsaturated fatty acids and human cytokine synthesis
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DOI：
10.1007/bf02637083
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发表时间：
1996-03-01
期刊：
影响因子：
1.9
通讯作者：
Endres, S
中科院分区：
文献类型：
--
作者：
Endres, S
细胞因子白细胞介素-1和肿瘤坏死因子-a是免疫应答的有效肽介质。它们在纳摩尔浓度下对靶组织（从血管内皮到中枢神经系统和免疫活性细胞）发挥强效细胞效应。这两种细胞因子的合成可被类固醇和其他免疫抑制剂如环孢菌素A抑制。在以前的研究中，我们已经发现，这种炎症细胞因子合成的抑制也可以通过增加白细胞膜中n-3多不饱和脂肪酸的含量来实现。
The cytokines interleukin-1 and tumor necrosis factor-a are potent peptide mediators of the immune response. They exert potent cellular effects at nanomolar concentrations with target tissues ranging from the vascular endothelium, to the central nervous system and immunocompetent cells. The synthesis of these two cytokines can be suppressed pharmacologically by steroids and other immunosuppressive agents such as cyclosporin A. In previous studies we have found that such an inhibition of inflammatory cytokine synthesis can also be achieved by increasing the content of n-3 polyunsaturated fatty acids in leukocyte membranes.