Xestosaprols from the Indonesian Marine Sponge Xestospongia sp.
Xestosaprols from the Indonesian Marine Sponge Xestospongia sp.
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DOI：
10.1021/np100203x
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发表时间：
2010-06-01
影响因子：
5.1
通讯作者：
Williams, Philip G.
中科院分区：
文献类型：
--
作者：
Dai, Jingqiu;Sorribas, Analia;Williams, Philip G.
Eight pentacyclic compounds, xestosaprols F-M (1-8), were isolated from a marine sponge belonging to the genus Xestaspongia. The structures of these new compounds were determined on the basis of extensive analyses of NMR experiments and mass spectrometric measurements. These compounds inhibited the aspartic protease BACE I at moderate levels ill a dose-dependent manner.
