Taurine: an osmolyte in mammalian tissues.
Taurine: an osmolyte in mammalian tissues.
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DOI：
10.1007/978-1-4899-0117-0_27
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发表时间：
1998
影响因子：
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通讯作者：
H. Pasantes‐morales;O. Quesada;J. Morán
中科院分区：
文献类型：
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作者：
H. Pasantes‐morales;O. Quesada;J. Morán
牛磺酸的一个显著特征是它在大多数动物组织中含量很高。虽然细胞和物种之间存在差异，但牛磺酸在mM浓度中一致存在。值得注意的是，包括脑、纹状肌和心脏在内的可兴奋组织含有大量的、惰性的和细胞内的牛磺酸池。在这方面最突出的例子是视网膜。到目前为止，在所有被检测的物种中，视网膜牛磺酸水平超过20毫米，在一些物种中其浓度高达60毫米。除了这些高水平，牛磺酸在可兴奋组织有一个非常缓慢的周转率。在大鼠各器官中，牛磺酸周转率可分为三大类：1天内计算速度较快的包括肝、肾和胰腺；第二组为肺、脾、肠、睾丸、骨髓，中间速率约为2-3天；第三组为脑、心脏、肌肉，速度最慢，为3天以上，最多7天；
One of the distinctive features of taurine is its presence at high levels in most animal tissues5,3. Although differences exist among cells and species, taurine is consistently found in mM concentrations. It is noteworthy that excitable tissues including brain, striatal muscle and heart contain large, inert, and intracellular taurine pools3,9. The most prominent example in this respect is the retina. In all species so far examined, retinal taurine levels exceed 20 mM and in some species its concentration is as high as 60 mM39. In addition to these high levels, taurine in excitable tissues has a very slow turnover rate. In rat organs, values for taurine turnover rate fit into three main groups: those with a relatively fast rate calculated in less than 1 day and include liver, kidney and pancreas; a second group, with a medium rate of about 2–3 days comprises lung, spleen, intestine, testes, bone marrow and the third group, with the slowest rate of more than 3 days and up to 7 days, is represented by brain, heart and muscle30;.