Prevalence of and factors associated with sarcopenia in elderly patients with end-stage renal disease
Prevalence of and factors associated with sarcopenia in elderly patients with end-stage renal disease
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DOI：
10.1016/j.clnu.2013.04.002
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发表时间：
2014-02-01
影响因子：
6.3
通讯作者：
Song, Young Rim
中科院分区：
文献类型：
--
作者：
Kim, Jwa-Kyung;Choi, Sun Ryoung;Song, Young Rim
背景与目的：研究老年终末期肾病（ESRD）患者肌肉减少症的患病率及其与营养、认知功能、抑郁症状、炎症和β 2微球蛋白等指标的关系。方法：对95例50岁以上ESRD患者进行横断面研究。肌肉减少症被定义为肌肉质量和力量的下降。结果：平均年龄63.9±10.0岁；56.8%为男性，52.6%为糖尿病患者。骨骼肌减少症在老年ESRD患者中非常普遍（男性37.0%，女性29.3%）。主观总体评估（SGA）、炎症标志物和β 2微球蛋白水平与肌肉减少症显著相关，即使在调整了年龄、性别、糖尿病和体重指数后也是如此。此外，与无抑郁症状的患者相比，有抑郁症状的患者出现肌肉减少症的风险更高（优势比，OR = 6.87, 95%可信区间，CI = 2.06-22.96），轻度认知功能障碍患者更容易出现肌肉减少症（OR = 6.35, 95% Cl = 1.62-34.96）。结论：骨骼肌减少症在老年ESRD患者中非常普遍，并与SGA、炎症标志物、β 2微球蛋白、抑郁和认知功能障碍密切相关。(C) 2013爱思唯尔有限公司和欧洲临床营养与代谢学会。版权所有。
Background & aims: We investigated the prevalence of sarcopenia in elderly patients with end-stage renal disease (ESRD) and its relationship with various markers of nutrition, cognitive function, depressive symptoms, inflammation and beta 2-microglobulin.Methods: A cross-sectional study was conducted with 95 patients having ESRD aged over 50 years. Sarcopenia was defined as a decline in both muscle mass and strength.Results: The mean age was 63.9 +/- 10.0 years; 56.8% were men and 52.6% had diabetes. Sarcopenia was highly prevalent in elderly patients with ESRD (37.0% in men and 29.3% in women). Subjective Global Assessment (SGA), inflammatory markers and beta 2-microglobulin levels were significantly associated with sarcopenia, even after adjustment for age, gender, diabetes, and body mass index. Additionally, patients with depressive symptoms showed a higher risk of sarcopenia relative to those without depressive symptoms (odds ratio, OR = 6.87, 95% confidence interval, CI = 2.06-22.96) and sarcopenia was more likely to be present in patients with mild cognitive dysfunction (OR = 6.35, 95% Cl = 1.62-34.96).Conclusions: Sarcopenia is highly prevalent in elderly patients with ESRD and is closely associated with SGA, inflammatory markers, beta 2-microglobulin, depression and cognitive dysfunction. (C) 2013 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.