The Maudsley family study .2. Endogenous event-related potentials in familial schizophrenia
The Maudsley family study .2. Endogenous event-related potentials in familial schizophrenia
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DOI：
10.1016/s0920-9964(96)00089-8
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发表时间：
1997-01-17
影响因子：
4.5
通讯作者：
Murray, RM
中科院分区：
文献类型：
--
作者：
Frangou, S;Sharma, T;Murray, RM
对16个精神分裂症家系的33名精神分裂症患者、57名非精神分裂症一级亲属和32名健康对照者进行了听觉事件相关电位（ERPs）检测。精神分裂症在这些家庭中的传播似乎是单线性的，父母中只有一方传播这种疾病。因此，我们能够确定10个假定的专性载体和研究其中8个。与对照组相比，精神分裂症患者表现出N100、N200和P300波的潜伏期延长和振幅降低。与对照组相比，他们的亲属表现出类似的异常。亲属中P300潜伏期有双峰分布的趋势，其中20人（35%）落在对照组平均值的两个标准差之外。其中包括八个义务承运人中的六个。我们的研究结果表明，ERP异常可能作为精神分裂症的遗传易感性的标志，并可能是有用的遗传连锁研究。
Auditory event-related potentials (ERPs) were obtained from 33 schizophrenics, from 16 families multiply affected with schizophrenia, 57 of their non-schizophrenic first-degree relatives and 32 unrelated healthy controls. Transmission of schizophrenia in these families appeared unilinear with one parent only transmitting the disorder. Consequently, we were able to identify 10 presumed obligate carriers and study eight of them. Schizophrenic patients showed latency prolongation and amplitude reduction of the N100, N200 and P300 waves compared to controls. Their relatives showed similar abnormalities compared to controls. There was a trend for bimodal distribution of the P300 latency in the relatives, with 20 (35%) of them falling outside two standard deviations of the mean of the controls. These included six of the eight obligate carriers. Our results suggest that ERP abnormalities may serve as markers of genetic vulnerability in schizophrenia and may be useful in genetic linkage studies.