Antiretroviral therapy adherence and self-efficacy among people living with HIV and a history of drug use in Vietnam.
Antiretroviral therapy adherence and self-efficacy among people living with HIV and a history of drug use in Vietnam.
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DOI：
10.1177/0956462417696431
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发表时间：
2017-10
影响因子：
1.4
通讯作者：
Tuan NA
中科院分区：
文献类型：
--
作者：
Li L;Lin C;Lee SJ;Tuan LA;Feng N;Tuan NA
有吸毒史的艾滋病毒携带者面临着额外的心理社会挑战，这可能会影响他们对抗逆转录病毒治疗(ART)的坚持。这项研究调查了越南有吸毒史的艾滋病毒携带者的抗逆转录病毒治疗依从性和依从性自我效能。我们使用了2014年10月至2015年2月在越南进行的一项随机对照试验收集的横断面基线数据。在试验中的900名有吸毒史的人中，109名目前接受抗逆转录病毒治疗的艾滋病毒携带者的样本包括在研究中。绝大多数(92%)的参与者报告说在过去的30天里没有错过任何药物。多元回归分析显示，社会支持与服药依从性自我效能感(β=0.420，P<；0.001)和一般服药依从性(β=0.201，P=0.0368)呈正相关。对抗逆转录病毒治疗的总体依从性与抑郁症状(β=−0.188，P=0.046)和当前海洛因使用(β=−0.196，P=0.042)呈负相关。这些发现强调了解决有吸毒史的艾滋病毒携带者面临的心理健康和社会挑战的重要性，以促进抗逆转录病毒治疗的坚持。HIV的临床管理应该识别和解决同时使用物质的行为，以最大限度地坚持和治疗结果。
People living with HIV with a history of drug use face additional psychosocial challenges that could compromise their adherence to antiretroviral therapy (ART). This study examined ART treatment adherence and adherence self-efficacy among people living with HIV with a history of drug use in Vietnam. We used cross-sectional baseline data collected between October 2014 and February 2015 from a randomized controlled trial in Vietnam. Of the 900 persons with a history of drug use in the trial, a sample of 109 people living with HIV currently on ART were included in the study. The vast majority (92%) of the participants reported not missing any medications in the past 30 days. Multiple regression results indicated that social support was positively associated with adherence self-efficacy (β = 0.420, P < 0.001) and general adherence to ART (β = 0.201, P = 0.0368). General adherence to ART was negatively associated with depressive symptoms (β = −0.188, P = 0.046) and current heroin use (β = −0.196, P = 0.042). These findings underscore the importance of addressing mental health and social challenges facing people living with HIV with a history of drug use to promote ART treatment adherence. Clinical management of HIV should identify and address concurrent substance use behaviors to maximize adherence and treatment outcomes.