Polyelectrolyte multilayers for tunable release of antibiotics
Polyelectrolyte multilayers for tunable release of antibiotics
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DOI：
10.1021/bm800185h
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发表时间：
2008-06-01
影响因子：
6.2
通讯作者：
Hammond, Paula T.
中科院分区：
文献类型：
--
作者：
Chuang, Helen F.;Smith, Renee C.;Hammond, Paula T.
采用逐层沉积法制备了含有庆大霉素的聚电解质多层膜。该多层膜可精确调节用量，并可控制在水生理条件下的释放速度。该膜对金黄色葡萄球菌有效，对小鼠成骨细胞MC3T3无毒。这些薄膜是用一层一层的工艺制造的，其结构结构代表了一种将带电的小分子物种结合到聚电解质多层膜中的一般策略，而不需要任何物理或化学预改性，扩大了这些薄膜中可以传递的活性物种的范围，同时保持了逐层制造工艺的便性。
Polyelectrolyte multilayers incorporating gentamicin were fabricated using layer-by-layer deposition. The multilayers could be precisely tuned with regard to dosage, and release rate under aqueous physiological conditions could be controlled. The films were demonstrated efficacious against Staphylococcus aureus and nontoxic toward murine osteoblasts MC3T3. The films were made in a layer-by-layer process with a hereto structural architecture that represents a general strategy for incorporating charged small molecular species into polyelectrolyte multilayers without the need for any physical or chemical premodification, expanding the range of active species that can be delivered from these films while maintaining the ease of layer-by-layer fabrication process.