TeloPIN: a database of telomeric proteins interaction network in mammalian cells.
TeloPIN: a database of telomeric proteins interaction network in mammalian cells.
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TeloPIN：哺乳动物细胞中端粒蛋白相互作用网络的数据库。
DOI：
10.1093/database/bav018
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发表时间：
2015-01-01
期刊：
影响因子：
--
通讯作者：
Xiong, Yuanyan
中科院分区：
文献类型：
--
作者：
Luo, Zhenhua;Dai, Zhiming;Xiong, Yuanyan
在过去的二十年中，围绕端粒的相互作用网络已经被广泛研究。然而，目前还没有通过整合端粒相互作用信息数据的特定资源。为了更好地理解端粒与生物学过程和疾病的分子相互作用网络，我们开发了一个新的数据库TeloPIN（Telomeric Proteins Interaction Network）（http：//songyanglab.sysu.edu.cn/telopin/），旨在提供端粒蛋白质-蛋白质、蛋白质-DNA和蛋白质-RNA相互作用的全面信息。TeloPIN数据库包含四种类型的相互作用数据，包括（i）蛋白质-蛋白质相互作用（PPI）数据，（ii）端粒蛋白质ChIP-seq数据，（iii）端粒相关蛋白质数据和（iv）端粒重复序列包含RNA（TERRA）相互作用蛋白质数据。通过分析这四种类型的相互作用数据，我们发现在人和小鼠细胞中分别有358和199个蛋白质具有不止一种类型的相互作用信息。我们还开发了表格浏览器和TeloChIP基因组浏览器，以帮助研究人员更好地集成可视化来自不同研究的相互作用数据。目前发布的TeloPIN数据库包括1111个PPI，8个端粒蛋白ChIP-seq数据集，1391个端粒相关蛋白和183个TERRA相互作用蛋白，来自92个独立的哺乳动物细胞研究。TeloPIN数据库提供的相互作用信息将极大地扩展我们对端粒蛋白相互作用网络的认识。
Interaction network surrounding telomeres has been intensively studied during the past two decades. However, no specific resource by integrating telomere interaction information data is currently available. To facilitate the understanding of the molecular interaction network by which telomeres are associated with biological process and diseases, we have developed TeloPIN (Telomeric Proteins Interaction Network) database (http://songyanglab.sysu.edu.cn/telopin/), a novel database that points to provide comprehensive information on protein-protein, protein-DNA and protein-RNA interaction of telomeres. TeloPIN database contains four types of interaction data, including (i) protein--protein interaction (PPI) data, (ii) telomeric proteins ChIP-seq data, (iii) telomere-associated proteins data and (iv) telomeric repeat-containing RNAs (TERRA)-interacting proteins data. By analyzing these four types of interaction data, we found that 358 and 199 proteins have more than one type of interaction information in human and mouse cells, respectively. We also developed table browser and TeloChIP genome browser to help researchers with better integrated visualization of interaction data from different studies. The current release of TeloPIN database includes 1111 PPI, eight telomeric protein ChIP-seq data sets, 1391 telomere-associated proteins and 183 TERRA-interacting proteins from 92 independent studies in mammalian cells. The interaction information provided by TeloPIN database will greatly expand our knowledge of telomeric proteins interaction network.