The effect of membrane domains on the G protein-phospholipase Cbeta signaling pathway.
The effect of membrane domains on the G protein-phospholipase Cbeta signaling pathway.
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DOI：
10.3109/10409231003598812
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发表时间：
2010-04
影响因子：
6.5
通讯作者：
Scarlata S
中科院分区：
文献类型：
--
作者：
Golebiewska U;Scarlata S
质膜作为一种屏障，限制组分进出细胞，提供对外部环境的保护。细胞与外界环境之间的通讯是由多种信号通路介导的。虽然质膜历来被视为具有自由扩散的蛋白质的脂质双分子层，但过去十年已经表明，质膜中的脂质和蛋白质以非随机方式组织，并且这种组织可以指导和修改细胞中的各种信号通路。在这篇综述中，我们定性地讨论了膜结构域影响细胞信号传导的方式。然后，我们关注膜结构域如何影响特定的信号通路- G蛋白-磷脂酶Cβ途径，并展示膜结构域如何在指导或重定向G蛋白信号中发挥积极作用。
The plasma membrane serves as a barrier to limit the exit and entry of components into and out of the cell offering protection from the external environment. Communication between the cell and the external environment is mediated by multiple signaling pathways. While the plasma membrane was historically viewed as a lipid bilayer with freely diffusing proteins, the last decade has shown that the lipids and proteins in the plasma membrane are organized in a non-random manner, and that this organization can direct and modify various signaling pathways in the cell. In this review, we qualitatively discuss the ways that membrane domains can affect cell signaling. We then focus on how membrane domains can affect a specific signaling pathways – the G protein – phospholipase Cβ pathway and show how membrane domains can play an active role in directing or redirecting G protein signals.
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影响因子：
3.4
作者：
Golebiewska, Urszula;Scarlata, Suzanne
通讯作者：
Scarlata, Suzanne
影响因子：
7.8
作者：
Kenworthy, Anne K;Nichols, Benjamin J;Remmert, Catha L;Hendrix, Glenn M;Kumar, Mukesh;Zimmerberg, Joshua;Lippincott-Schwartz, Jennifer
通讯作者：
Lippincott-Schwartz, Jennifer
影响因子：
64.5
作者：
BERSTEIN, G;BLANK, JL;ROSS, EM
通讯作者：
ROSS, EM
影响因子：
4.1
作者：
Ballou, LM;Chattopadhyay, M;Lin, RZ
通讯作者：
Lin, RZ
影响因子：
4.8
作者：
Ballou, LM;Lin, HY;Lin, RZ
通讯作者：
Lin, RZ