SARS-CoV-2 and Placenta: New Insights and Perspectives.
SARS-CoV-2 and Placenta: New Insights and Perspectives.
复制标题
DOI：
10.3390/v13050723
复制
发表时间：
2021-04-21
期刊：
影响因子：
--
通讯作者：
Rossi R
中科院分区：
文献类型：
--
作者：
Resta L;Vimercati A;Cazzato G;Mazzia G;Cicinelli E;Colagrande A;Fanelli M;Scarcella SV;Ceci O;Rossi R
对SARS-CoV-2阳性孕妇的研究对妇产科医生、产科医生、妇产科医生和妇女本身都有一定的意义。最近几个月，新的研究试图阐明病毒阳性妇女在胎儿-胎盘水平上发生了什么，并提出了不同的发病机制。在这里，我们提出了一个大系列的冠状病毒病（COVID）阳性妇女的胎盘的结果，在COVID阳性妊娠的参考中心，我们进行了组织学，免疫组织化学和电子显微镜调查。进行了病例对照研究，以突出任何归因于SARS-CoV-2的组织病理学改变。母体血管灌注不良的患病率在病例组和对照组之间无显著差异（54.3% vs. 43.7% p = 0.19），而胎儿血管灌注不良的患病率差异（21.1% vs. 4.2% p < 0.001）则显著。与对照组相比，病例中更常见的是蜕膜动脉病（40.9% vs. 1.4% p < 0.0001）、蜕膜炎症（32.4% vs. 0.7% p < 0.0001）、绒毛周围纤维蛋白沉积（36.6% vs. 3.5% p < 0.0001）和胎儿血管血栓（22.5% vs. 0.7% p < 0.0001）。两组间终末绒毛增生和绒毛膜炎的百分比无显著差异。随着大流行的持续，这些研究将变得更加紧迫，以澄清病毒母婴传播的可能机制。
The study of SARS-CoV-2 positive pregnant women is of some importance for gynecologists, obstetricians, neonatologists and women themselves. In recent months, new works have tried to clarify what happens at the fetal–placental level in women positive for the virus, and different pathogenesis mechanisms have been proposed. Here, we present the results of a large series of placentas of Coronavirus disease (COVID) positive women, in a reference center for COVID-positive pregnancies, on which we conducted histological, immunohistochemical and electron microscopy investigations. A case–control study was conducted in order to highlight any histopathological alterations attributable to SARS-CoV-2. The prevalence of maternal vascular malperfusion was not significantly different between cases and controls (54.3% vs. 43.7% p = 0.19), whereas the differences with regard to fetal vascular malperfusion (21.1% vs. 4.2% p < 0.001) were significant. More frequent in cases with respect to controls were decidual arteriopathy (40.9% vs. 1.4% p < 0.0001), decidual inflammation (32.4% vs. 0.7% p < 0.0001), perivillous fibrin deposition (36.6% vs. 3.5% p < 0.0001) and fetal vessel thrombi (22.5% vs. 0.7% p < 0.0001). No significant differences in the percentage of terminal villous hyperplasia and chorioamnionitis were observed between the two groups. As the pandemic continues, these studies will become more urgent in order to clarify the possible mechanism of maternal–fetal transmission of the virus.
登录
查看更多内容
DOI：
10.1111/1471-0528.16403
发表时间：
2020-08-13
影响因子：
5.8
作者：
Prabhu, M.;Cagino, K.;Riley, L. E.
通讯作者：
Riley, L. E.
影响因子：
3.6
作者：
Sisman, Julide;Jaleel, Mambarambath A.;Evans, Amanda S.
通讯作者：
Evans, Amanda S.
影响因子：
105.7
作者：
Knight, Marian;Bunch, Kathryn;Kurinczuk, Jennifer J.
通讯作者：
Kurinczuk, Jennifer J.
DOI：
10.1080/14767058.2020.1786056
发表时间：
2020-07-16
影响因子：
1.8
作者：
Takemoto, Maira L. S.;Menezes, Mariane O.;Amorim, Melania M. R.
通讯作者：
Amorim, Melania M. R.
影响因子：
5
作者：
Menter, Thomas;Mertz, Kirsten Diana;Bruder, Elisabeth
通讯作者：
Bruder, Elisabeth