Spontaneous calcium signals induced by gap junctions in a network model of astrocytes
Spontaneous calcium signals induced by gap junctions in a network model of astrocytes
复制标题
DOI：
10.1103/physreve.79.010901
复制
发表时间：
2009-01-01
影响因子：
2.4
通讯作者：
Kazantsev, V. B.
中科院分区：
文献类型：
--
作者：
Kazantsev, V. B.
研究了星形胶质细胞间隙连接网络模型的动力学。单细胞的钙动力学用由三个非线性微分方程组成的生物物理模型来描述。细胞间动力学是由肌醇1,4,5-三磷酸（IP3）通过相邻星形胶质细胞之间的间隙连接扩散提供的。研究发现，扩散诱导了神经网络中自发活动模式的出现。分析了网络稳态的稳定性。证明了扩散系数增大到一定临界值以上，在一定频率范围内产生低幅值的亚阈值振荡信号。研究表明，这种自发振荡可以促进钙脉冲的产生，并在星形胶质细胞信号传导中提供一定的时间尺度。
The dynamics of a network model of astrocytes coupled by gap junctions is investigated. Calcium dynamics of the single cell is described by the biophysical model comprising the set of three nonlinear differential equations. Intercellular dynamics is provided by the diffusion of inositol 1,4,5-trisphosphate (IP3) through gap junctions between neighboring astrocytes. It is found that the diffusion induces the appearance of spontaneous activity patterns in the network. Stability of the network steady state is analyzed. It is proved that the increase of the diffusion coefficient above a certain critical value yields the generation of low-amplitude subthreshold oscillatory signals in a certain frequency range. It is shown that such spontaneous oscillations can facilitate calcium pulse generation and provide a certain time scale in astrocyte signaling.