Ectopic adrenergic sensitivity in damaged peripheral nerve axons in the rat
Ectopic adrenergic sensitivity in damaged peripheral nerve axons in the rat
复制标题
大鼠周围神经轴突受损的异位肾上腺素敏感性
DOI：
10.1016/0014-4886(81)90127-8
复制
发表时间：
1981
影响因子：
5.3
通讯作者：
M. Devor
中科院分区：
文献类型：
--
作者：
E. Korenman;M. Devor
单纤维记录神经末端神经瘤中异位产生的脉冲。大多数自发活动的感觉纤维和其他一些沉默的感觉纤维对肾上腺素能激动剂有反应，这些激动剂通过颈静脉注入动脉或全身循环。有α-肾上腺素能药理作用。运动纤维是不敏感的。为了获得相同的神经反应，静脉注射剂量约为动脉注射剂量的10倍。许多神经瘤纤维对局部缺血有反应。然而，对肾上腺素的反应仍可在缺血性神经瘤中得到证实。因此，肾上腺素能刺激的效果不仅仅是由于局部血流的变化。节前交感神经柱的强电刺激改变了完整和肾上腺切除大鼠的神经瘤放电，其方式与全身性肾上腺素相同。结果支持了受损感觉轴突产生异位α-肾上腺素能受体的假设，使它们对交感神经活动敏感。这可能解释了手术和化学交感神经切除术在减轻某些周围神经损伤病例疼痛方面的成功。
Single-fiber recordings were made of impulses generated ectopically in nerve end neuromas. Most spontaneously active sensory fibers and some otherwise silent sensory fibers responded to adrenergic agonists injected close arterially or into the general circulation by way of the jugular vein. There was α-adrenergic pharmacology. Motor fibers were insensitive. To obtain equivalent neural responses, an intravenous dose about 10 times the close arterial dose was required. Many neuroma fibers responded to local ischemia. The response to adrenalin, however, could still be demonstrated in ischemic neuromas. The effect of adrenergic stimulation is therefore not due solely to a local change of blood flow. Tetanic stimulation of the preganglionic sympathetic column altered neuroma discharge in both intact and adrenalectomized rats in the same way that systemic adrenalin did. The results support the hypothesis that damaged sensory axons develop ectopic α-adrenergic receptors that render them sensitive to sympathetic activity. This might explain the success of surgical and chemical sympathectomy in alleviating pain in some cases of peripheral nerve injury.