Aqueous Flare and Progression of Visual Field Loss in Patients With Retinitis Pigmentosa.
Aqueous Flare and Progression of Visual Field Loss in Patients With Retinitis Pigmentosa.
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色素性视网膜炎患者的房水耀斑和视野丧失的进展。
DOI：
10.1167/iovs.61.8.26
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Sonoda KH.
中科院分区：
文献类型：
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作者：
Fujiwara K;Ikeda Y;Murakami Y;Tachibana T;Funatsu J;Koyanagi Y;Nakatake S;Shimokawa S;Yoshida N;Nakao S;Hisatomi T;Ishibashi T;Sonoda KH.
目的：目的：探讨视网膜色素变性（retinitis pigmentosa. RP. Methods）患者房水闪辉与视野缺损进展的关系。方法：我们对101例101只眼确诊为典型视网膜色素变性的患者进行了检查。61%的患者为女性，总组的平均年龄为47.4岁。获得所有患者的房水闪辉、视野（通过Humphrey视野分析仪，中央10-2 SITA标准程序）和光学相干断层扫描测量值。斜率，这是从平均偏差，黄斑敏感性，或中央凹敏感性的一系列值为每只眼睛与单变量线性回归，用于分析。房水闪辉值与平均偏差斜率显著相关（r=-0.20，P= 0.046）、黄斑敏感度斜率（r=-0.28，P= 0.005）和中心凹敏感度斜率（r=-0.20，P= 0.047）。视网膜敏感度斜率值随房水闪辉程度的增加而显著降低（均P< 0.05）。这些协会保持不变调整后的年龄，性别，后囊下白内障，和epiretinal membranes.Conclusions：海拔的水闪是RP的中央视功能下降的危险因素。房水闪光可能是RP疾病进展的有用标志物。
Purpose: To investigate the association between aqueous flare and progression of visual field loss using the Humphrey Field Analyzer in patients with retinitis pigmentosa (RP).Methods: We examined a total of 101 eyes of 101 patients who were diagnosed with typical RP. Sixty-one percent of the patients were female, and the mean age of the total group was 47.4 years. Aqueous flare, visual field (by an Humphrey Field Analyzer, the central 10-2 SITA-Standard program), and optical coherence tomography measurements were obtained for all patients. The slope, which was derived from serial values of mean deviation, macular sensitivity, or foveal sensitivity for each eye with univariate linear regression, was used for analysis.Results: Aqueous flare values were significantly correlated with the mean deviation slope (r=− 0.20, P= 0.046), macular sensitivity slope (r=− 0.28, P= 0.005) and foveal sensitivity slope (r=− 0.20, P= 0.047). The values of the retinal sensitivity slope significantly decreased as the aqueous flare level increased (all P< 0.05). These associations remained unchanged after adjustment for age, sex, and posterior subcapsular cataract, and epiretinal membrane.Conclusions: Elevation of aqueous flare is a risk factor for the decline of central visual function in RP. Aqueous flare may be a useful marker for disease progression in RP.