[Chronic inflammatory demyelinating polyradiculoneuropathy and hyponatremia in a patient with chronic graft versus host disease].
[Chronic inflammatory demyelinating polyradiculoneuropathy and hyponatremia in a patient with chronic graft versus host disease].
复制标题
DOI：
10.5692/clinicalneurol.48.426
复制
发表时间：
2008-06
期刊：
影响因子：
--
通讯作者：
S. Wada;Takashi Kimura;K. Ikegame;K. Kajiyama;M. Takeda;H. Yoshikawa
中科院分区：
文献类型：
--
作者：
S. Wada;Takashi Kimura;K. Ikegame;K. Kajiyama;M. Takeda;H. Yoshikawa
2003年，一名54岁的妇女因急性淋巴细胞白血病接受化疗，在50岁时出现手脚感觉迟钝。第二年，她接受了造血干细胞移植。2005年，她被诊断出患有慢性移植物抗宿主病（cGVHD）。2006年12月，患者出现面部和舌头感觉迟钝（发病）。发病50天后，她出现呼吸道感染。10天后，患者因四肢肌无力和感觉迟钝进展住院。神经传导研究和腓浅神经活检显示脱髓鞘。经过大剂量免疫球蛋白治疗后，她的肌肉力量恢复了。通过限制液体摄入和给予NaCl解决了低钠血症。我们认为免疫机制如cGVHD可能导致慢性炎性脱髓鞘性多发性神经根神经病和低钠血症。
A 54-year-old woman, who was treated with chemotherapy for acute lymphoblastic leukemia, developed dysesthesia in her hands and feet at the age of 50 in 2003. The following year she underwent hematopoietic stem cell transplantation. In 2005, she was diagnosed with chronic graft versus host disease (cGVHD). In December 2006, she developed dysesthesia in her face and tongue (onset). 50 days after the onset, she had a respiratory infection. 10 days later, she was hospitalized for muscle weakness of four extremities and progression of dysesthesia. Nerve conduction studies and superficial peroneal nerve biopsy revealed demyelination. After high-dose immunoglobulin therapy, her muscle strength recovered. Hyponatremia was resolved by restriction of fluid intake and administration of NaCl. We suggest immunological mechanisms such as cGVHD may cause chronic inflammatory demyelinating polyradiculoneuropathy and hyponatremia.