The common occurrence of human papillomavirus infection and intraepithelial neoplasia in women infected by HIV.
The common occurrence of human papillomavirus infection and intraepithelial neoplasia in women infected by HIV.
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感染艾滋病毒的女性常见人乳头瘤病毒感染和上皮内瘤变。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
J. Harris
中科院分区：
文献类型：
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作者：
M. Byrne;D. Taylor;P. Munday;J. Harris
在19名临床表现良好但感染艾滋病毒的妇女中，有18名显示下生殖道异常。7例患者有上皮内瘤变，其中5例经组织学证实，4例发生在宫颈，3例发生在外阴，1例发生在会阴。在这些妇女以及其他11名感染艾滋病毒的妇女中的10名中发现了与人乳头瘤病毒（HPV）感染相容的病变（临床和/或亚临床）。一半的患者在一个以上的部位发现了疾病，如果没有进行阴道镜检查，一半以上的患者会保持隐蔽。感染艾滋病毒的妇女感染人类乳头瘤病毒和发生下生殖道肿瘤的风险很高。
Eighteen out of 19 women who were clinically well but infected by HIV showed abnormalities of the lower genital tract. Seven patients had intraepithelial neoplasia, histologically verified in five, involving the cervix in four, the vulva in three and the perineum in one. Lesions (clinical and/or subclinical) compatible with human papillomavirus (HPV) infection were identified in these women, as well as in 10 out of the other 11 women infected with HIV. Disease at more than one site was detected in half of the patients and would have remained covert in more than half, had colposcopy not been undertaken. Women with HIV infection are at high risk of harbouring HPV and of developing lower genital tract neoplasia.