Risk of adverse reproductive outcomes associated with proximity to municipal solid waste incinerators with high dioxin emission levels in Japan
Risk of adverse reproductive outcomes associated with proximity to municipal solid waste incinerators with high dioxin emission levels in Japan
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DOI：
10.2188/jea.14.83
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发表时间：
2004-05-01
影响因子：
4.7
通讯作者：
Uehata, T
中科院分区：
文献类型：
--
作者：
Tango, T;Fujita, T;Uehata, T
背景：在日本，公众越来越关注城市固体废物焚烧炉排放的二恶英对健康的影响。本文调查了不良生殖结果与母亲居住地邻近城市固体废物焚化炉的关系。方法：研究了日本63个高二恶英排放水平（超过80 ng国际毒性当量TEQ/m（3））的城市固体废物焚化炉10 km范围内母亲不良生殖结果的关系。将观察到的病例数与根据经区域调整的国家发病率计算的预期数字进行了比较。观察/预期的比率进行了测试的风险下降或峰值下降的风险与距离达10 km.Results：在研究区域内10公里的63个城市固体废物焚烧炉在19971998年，225,215活产，3,387胎儿死亡，835婴儿死亡被确认。在这里研究的生殖结果没有显示出统计学上显着的过剩2公里内的焚化炉。然而，婴儿死亡的风险随着距离焚化炉10公里而出现统计学显著的峰值下降（p=0.023）和合并所有先天性畸形的婴儿死亡（p=0.047），其中在1-2 km附近检测到“峰值”。我们的研究表明，婴儿死亡和婴儿死亡与所有先天性畸形合并的风险随着与城市固体废物焚化炉的距离而下降。然而，由于缺乏详细的信息暴露于二恶英焚化炉周围，观察到的风险趋势应谨慎解释，有必要进行进一步的调查，以积累良好的证据，废物焚化炉暴露的生殖健康的影响。
BACKGROUND: Great public concern about health effects of dioxins emitted from municipal solid waste incinerators has increased in Japan. This paper investigates the association of adverse reproductive outcomes with maternal residential proximity to municipal solid waste incinerators.METHODS: The association of adverse reproductive outcomes with mothers living within 10 km from 63 municipal solid waste incinerators with high dioxin emission levels (above 80 ng international toxic equivalents TEQ/m(3)) in Japan was examined. The numbers of observed cases were compared with the expected numbers calculated from national rates adjusted regionally. Observed/expected ratios were tested for decline in risk or peak-decline in risk with distance up to 10 km.RESULTS: In the study area within 10 km from the 63 municipal solid waste incinerators in 19971998, 225,215 live births, 3,387 fetal deaths, and 835 infant deaths were confirmed. None of the reproductive outcomes studied here showed statistically significant excess within 2 km from the incinerators. However, a statistically significant peak-decline in risk with distance from the incinerators up to 10 km was found for infant deaths (p=0.023) and infant deaths with all congenital malformations combined (p=0.047), where a "peak" is detected around 1-2 km.CONCLUSION: Our study shows a peak-decline in risk with distance from the municipal solid waste incinerators for infant deaths and infant deaths with all congenital malformations combined. However, due to the lack of detailed exposure information to dioxins around the incinerators, the observed trend in risk should be interpreted cautiously and there is a need for further investigation to accumulate good evidence regarding the reproductive health effects of waste incinerator exposure.