Lens opacities in a rural population of southern India: The aravind comprehensive eye study
Lens opacities in a rural population of southern India: The aravind comprehensive eye study
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DOI：
10.1167/iovs.03-0011
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发表时间：
2003-11-01
影响因子：
4.4
通讯作者：
Robin, AL
中科院分区：
文献类型：
--
作者：
Nirmalan, PK;Krishnadas, R;Robin, AL
目标.确定印度南部农村老年人群中透镜混浊的患病率。一项对5150名40岁及以上的人进行的横断面研究，这些人被选为印度南部泰米尔纳德邦南部三个地区的代表性样本的一部分。使用透镜混浊分类系统（LOCS）III和标准照片，在瞳孔扩张后通过裂隙灯对所有镜片的混浊和其他疾病进行分级和分类。明确的白内障定义为LOCS III核乳光≥ 3.0级和/或皮质性白内障≥ 3.0级和/或后囊下白内障（PSC）≥ 2.0级。在5150例受试者中，2499例（47.5%）单眼或双眼存在明确的白内障。该人群中明确白内障的年龄调整患病率（根据2000年美国人口估计值调整）为61.9%（95%CI，60.6 - 6.3）。男性的患病率显著较低（P = 0.0002）。白内障以核性白内障最常见（59.7%），皮质性白内障占20.0%，PSC占24.3%。9.4%的人进行了白内障手术，其中3.0%的人进行了双侧白内障手术。3.7%的无晶状体眼和0.8%的人工晶状体眼的最佳矫正视力低于6/60。在这一人群中，年龄调整后的患病率较高，年龄相关性白内障发病相对较早，这表明印度国家防盲计划采用的以白内障为中心的方法是适当的，可以最大限度地减少可预防的失明。
OBJECTIVES. To determine the prevalence of lens opacities in an older population in rural southern India.METHODS. A cross-sectional study of 5150 persons aged 40 years and more who were selected as part of a representative sample from three southern districts of the state of Tamil Nadu in southern India. All lenses were graded and classified for opacities and other disorders by slit lamp after pupillary dilation, using the Lens Opacification Classification System (LOCS) III and standard photographs. Definite cataract was defined as either LOCS III nuclear opalescence of grade 3.0 or more and/or cortical cataract of grade 3.0 or more and/or posterior subcapsular cataract (PSC) of grade 2.0 or more.RESULTS. Definite cataract was present in one or both eyes in 2499 (47.5%) of 5150 subjects. The age-adjusted prevalence (adjusted to U.S. population estimates for 2000) of definite cataract in this population was 61.9% (95% CI, 60.6 - 6.3). The prevalence was significantly lower in men (P = 0.0002). In those eyes with cataracts, nuclear cataract (59.7%) was most common, and cortical cataract was present in 20.0% and PSC in 24.3%. Cataract surgery had been performed in 9.4% persons, including 3.0% who had bilateral surgery for cataracts. Best corrected visual acuity was less than 6/60 in 3.7% of aphakic eyes and in 0.8% of pseudophakic eyes.CONCLUSIONS. The higher age-adjusted prevalence and relatively early onset of age-related cataract in this population suggest that the cataract-centered approach to minimizing preventable blindness, adopted by the National Program for Prevention of Blindness in India, is appropriate.