Lateralization of prefrontal activity during episodic memory retrieval: Evidence for the production-monitoring hypothesis
Lateralization of prefrontal activity during episodic memory retrieval: Evidence for the production-monitoring hypothesis
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DOI：
10.1162/089892903321208187
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发表时间：
2003-02-01
影响因子：
3.2
通讯作者：
Anderson, ND
中科院分区：
文献类型：
--
作者：
Cabeza, R;Locantore, JK;Anderson, ND
我们提出了一个新的假说，即在言语情景记忆提取过程中，前额叶皮层(PFC)的活动是偏侧化的。该假说表明，左侧PFC比右侧PFC更多地参与语义引导的信息产生，右侧PFC比左侧PFC更多地参与监控和验证。这一“生产监控假说”不同于现有的“系统-启发式假说”，后者认为左侧的PFC主要参与系统检索操作，而右侧的PFC主要参与启发式检索操作。为了比较这两种假设，我们使用正电子发射断层扫描(PET)测量了四种情景提取任务的PFC活动：主干线索回忆、联想线索回忆、上下文识别(来源记忆)和项目识别。回忆任务强调生产过程，而认知任务强调监控过程。主干线索回忆和上下文再认任务强调系统性操作，而联想线索回忆和项目再认任务强调启发式操作。与生产监控假说一致，左侧PFC对回忆任务的激活程度高于识别任务，右侧PFC对识别任务的激活程度高于对回忆任务的激活程度。与系统-启发式假设不同的是，左侧PFC对启发式任务的激活程度高于对系统性任务的激活程度，右侧PFC则相反。此外，这项研究还发现了PFC以外的激活差异。与先前的回忆/再认PET研究一致，前扣带回、小脑和纹状体区域在回忆任务中比在识别任务中更活跃，而在顶后区域则相反。与关联性线索回忆和项目再认相比，右侧内侧颞叶区域对主干线索回忆和背景再认的激活程度更高，这可能反映了知觉整合。总之，这些结果为生产监控假说提供了证据，并阐明了不同大脑区域在正电子发射计算机断层扫描和功能性磁共振成像(FMRI)对情景提取的研究中典型激活的作用。
We propose a new hypothesis concerning the lateralization of prefrontal cortex (PFC) activity during verbal episodic memory retrieval. The hypothesis states that the left PFC is differentially more involved in semantically guided information production than is the right PFC, and that the right PFC is differentially more involved in monitoring and verification than is the left PFC. This "production-monitoring hypothesis'' differs from the existing "systematic-heuristic hypothesis,'' which proposes that the left PFC is primarily involved in systematic retrieval operations, and the right PFC in heuristic retrieval operations. To compare the two hypotheses, we measured PFC activity using positron emission tomography (PET) during the performance of four episodic retrieval tasks: stem cued recall, associative cued recall, context recognition (source memory), and item recognition. Recall tasks emphasized production processes, whereas recognition tasks emphasized monitoring processes. Stem cued recall and context-recognition tasks underscored systematic operations, whereas associative cued recall and item-recognition tasks underscored heuristic operations. Consistent with the production-monitoring hypothesis, the left PFC was more activated for recall than for recognition tasks and the right PFC was more activated for recognition than for recall tasks. Inconsistent with the systematic-heuristic hypothesis, the left PFC was more activated for heuristic than for systematic tasks and the right PFC showed the converse result. Additionally, the study yielded activation differences outside the PFC. In agreement with a previous recall/ recognition PET study, anterior cingulate, cerebellar, and striatal regions were more activated for recall than for recognition tasks, and the converse occurred for posterior parietal regions. A right medial temporal lobe region was more activated for stem cued recall and context recognition than for associative cued recall and item recognition, possibly reflecting perceptual integration. In sum, the results provide evidence for the production-monitoring hypothesis and clarify the role of different brain regions typically activated in PET and functional magnetic resonance imaging (fMRI) studies of episodic retrieval.