Diverse roles of the vasculature within the neural stem cell niche.
Diverse roles of the vasculature within the neural stem cell niche.
复制标题
DOI：
10.2217/rme.09.61
复制
发表时间：
2009-11
影响因子：
2.7
通讯作者：
Hirschi KK
中科院分区：
文献类型：
--
作者：
Goldberg JS;Hirschi KK
血管系统和神经系统之间的相互依赖关系始于发育的最早阶段，并贯穿哺乳动物的整个生命周期。因此，成年神经发生的过程涉及两个系统的协调反应，以维持一个专门的微环境（生态位），根据需要将规模推向维持或再生。了解这种平衡的性质和调节将为开发基于分子和干细胞的疗法以治疗普遍的CNS疾病和障碍提供基础。血管系统被认为是成体脑室下区和颗粒下区（已知的成体神经干细胞壁龛）内的突出特征，有助于保留神经干细胞和祖细胞潜能。神经干细胞龛内的血管隔室具有独特的机会，不仅通过与构成血管的内皮细胞和壁细胞直接接触并从其旁分泌信号传导来调节神经干细胞和祖细胞，而且还通过来自血液循环的可溶性因子的分布将系统信号整合到局部微环境中以调节干细胞龛行为。了解复杂的作用，血管系统发挥影响神经干细胞的环境中的小生境调节将有助于弥合差距从板凳到床边的发展再生为基础的治疗中枢神经系统。
An interdependent relationship between the vascular and nervous systems begins during the earliest stages of development and persists through the mammalian lifespan. Accordingly, the process of adult neurogenesis involves the coordinated response of both systems to maintain a specialized microenvironment (niche) that tips the scale towards maintenance or regeneration, as needed. Understanding the nature and regulation of this balance will provide a foundation on which the potential for molecular-and stem cell-based therapies can be developed to treat prevalent CNS diseases and disorders. The vasculature is cited as a prominent feature within the adult subventricular zone and subgranular zone, known adult neural stem cell niches, helping to retain neural stem and progenitor cell potential. The vascular compartment within the neural stem cell niche has the unique opportunity to not only regulate neural stem and progenitor cells through direct contact with, and paracrine signaling from, endothelial and mural cells that make up blood vessels, but also integrates systemic signals into the local microenvironment via distribution of soluble factors from blood circulation to regulate stem cell niche behavior. Understanding the intricate role that the vasculature plays to influence neural stem cells in the context of niche regulation will help to bridge the gap from bench to bedside for the development of regeneration-based therapies for the CNS.