Feasibility of a Lifestyle Intervention on Body Weight and Serum Biomarkers in Breast Cancer Survivors with Overweight and Obesity
Feasibility of a Lifestyle Intervention on Body Weight and Serum Biomarkers in Breast Cancer Survivors with Overweight and Obesity
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DOI：
10.1016/j.jada.2011.10.022
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发表时间：
2012-04-01
影响因子：
4.8
通讯作者：
McKenzie, Donald C.
中科院分区：
文献类型：
--
作者：
Campbell, Kristin L.;Van Patten, Cheri L.;McKenzie, Donald C.
缺乏身体活动和超重或肥胖是生活方式因素，使乳腺癌幸存者处于癌症复发和/或其他慢性疾病发展的更高风险中。尽管如此，有有限的研究已经确定了有效的生活方式干预措施，专门针对乳腺癌幸存者的体重减轻。这项试点研究是一项单臂实验前后测试设计，从2009年11月至2010年7月进行，测试了24周基于小组的生活方式干预的有效性，以早期乳腺癌幸存者（N=14）的糖尿病预防计划为模型。干预包括由注册营养师领导的16次饮食会议和150分钟/周的中度至剧烈运动。在基线、24周和36周（非干预性随访）完成研究结局测量。主要结果是体重的变化，次要结果是身体成分、有氧健身、饮食摄入和血液生物标志物的变化。总体而言，参与者是年龄为54.6 ± 8.3岁的绝经后肥胖妇女（体重指数30.1 ± 3.6），并在2年前完成了辅助癌症治疗。结果显示，24周时平均体重减轻3.8 +/- 5.0 kg，体重指数、体脂百分比、腰围和臀围降低，36周时平均体重额外减轻0.8 +/- 1.2 kg。在探索性分析中，体重减轻>7%的参与者年龄较大，参加饮食和监督锻炼的比例更高。在24周和36周时，任何血液生物标志物均无显著变化;然而，结果为未来的研究提供了预期效应大小的测量。这项试点研究证明了基于糖尿病预防计划的生活方式干预在早期乳腺癌幸存者中的疗效，并代表了营养学从业者的创新临床干预，以解决未满足的计划需求。《营养饮食学会杂志》2012;112：559-567.
Physical inactivity and being overweight or obese are lifestyle factors that put breast cancer survivors at a higher risk for a cancer recurrence and/or development of other chronic diseases. Despite this, there is limited research that has identified effective lifestyle interventions aimed specifically at weight loss in breast cancer survivors. This pilot study is a single-arm experimental pre-post test design, conducted from November 2009 to July 2010, that tested the efficacy of a 24-week group-based lifestyle intervention modeled on the Diabetes Prevention Program in early stage breast cancer survivors (N=14). The intervention included 16 diet sessions led by a registered dietitian and 150 min/wk of moderate-to-vigorous exercise. Study outcame measures were completed at baseline, 24, and 36 weeks (nonintervention follow-up). The primary outcome was change in body weight, and secondary outcomes were change in body composition, aerobic fitness, dietary intake, and blood biomarkers. Overall, participants were postmenopausal women aged 54.6 +/- 8.3 years with obesity (body mass index 30.1 +/- 3.6), and had completed adjuvant cancer treatment 2 years prior. Results showed an average weight loss of 3.8 +/- 5.0 kg and a decrease in body mass index, percent body fat, and waist and hip circumferences at 24 weeks and an additional mean weight loss of 0.8 +/- 1.2 kg at 36 weeks. In exploratory analysis, participants who lost >7% body weight were older and attended a greater percentage of diet and supervised exercise sessions. There were no significant changes in any of the blood biomarkers at 24 and 36 weeks; however, the results provide a measure of expected effect size for future research studies. This pilot study demonstrated the efficacy of a lifestyle intervention based on the Diabetes Prevention Program in early stage breast cancer survivors and represents an innovative clinical intervention for dietetics practitioners to address the unmet need for programs. J Acad Nutr Diet. 2012;112:559-567.