Studies of Platelets
Studies of Platelets
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血小板研究
DOI：
10.1136/bmj.3.5563.449-a
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发表时间：
1962
影响因子：
--
通讯作者：
A. Lear
中科院分区：
文献类型：
--
作者：
J. J. Rheingold;E. Adelson;A. Lear
摘要：设计了一种在狗身上获得标记的年轻血小板队列的技术。这些研究表明，狗的血小板在体内连续凝血的过程中是随机破坏的。这一过程的半衰期为1.5天。狗的血小板在8天后开始老化死亡，12天后没有存活的血小板。然而，在正常狗中，只有不到2%的血小板在8天的破坏过程中存活下来，因此老化在决定血小板存活方面的作用可以忽略不计。华法林和肝素都不能完全阻止体内的凝血过程。然而，在这两种药物中，肝素似乎对狗更有效。一项在人类身上进行的可比性研究揭示了一个类似的随机过程，即通过体内连续凝血来破坏血小板。该过程的半衰期为2.8天。人血小板的衰老从第10天开始，第15天完成。只有不到3%的人血小板存活到第10天并衰老。肝素可将随机的血小板破坏过程从2.8天的正常半衰期减慢至7天的半衰期。(作者)
Abstract : A technique was devised for obtaining a cohort of tagged young platelets in dogs. These studies reveal that dog platelets are randomly destroyed by the process of continuous in vivo coagulation. This process results in a half-life of 1.5 days. Dog platelets begin to die by aging when they reach 8 days, and no platelets survive beyond 12 days of age. However, in the normal dog less than two percent of the platelets survive theANDOM PROCESS OF DESTRUCTION FOR 8 DAYS SO THAT AGING PLAYS A NEGLIGIBLE ROLE IN DETERMINING PLATELET SURVIVAL. Neither warfarin nor heparin is able completely to stop the process of in vivo coagulation. Of the two, however, heparin appears to be more effective in dogs. A comparable study in humans reveals a similar random process of platelets destruction by continuous in vivo coagulation. The half-life of this process is 2.8 days. Senescence for human platelets begins on day 10 and is complete by day 15. Less than 3% of human platelets survive to day 10 and senescence. Heparin slows the random process of platelet destruction from the normal half-life of 2.8 days to a half-life of 7 days. (Author)