Sequential changes in MR water proton relaxation time detect the process of rat brain myelination during maturation
Sequential changes in MR water proton relaxation time detect the process of rat brain myelination during maturation
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DOI：
10.1016/s0047-6374(01)00265-2
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发表时间：
2001-09-01
影响因子：
5.3
通讯作者：
Tsugane, R
中科院分区：
文献类型：
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作者：
Matsumae, M;Kurita, D;Tsugane, R
为了更好地理解水分子在动物脑中的行为，在大鼠成熟过程中研究了磁共振水质子弛豫过程的变化。在出生后2 - 70天的不同时间点取出雄性Wistar大鼠的中脑。弛豫时间的变化（水质子纵向弛豫时间的反转恢复，和水质子横向弛豫时间的自旋回波和Carr-Purcell-Meiboom-Gill脉冲序列（CPMG））和水含量，然后确定为大脑发育的各个阶段。在成熟过程中，水质子纵向弛豫时间和水质子横向弛豫时间值均减小，这一发现证实了含水量的下降。使用CPMG脉冲序列，观察到横向弛豫时间值在21天后分成两个分量。在形态学上，大鼠中脑发育成熟阶段最显著的变化是髓鞘形成。水质子弛豫时间，这可以估计使用CPMG脉冲序列，表现出密切的相关性与髓鞘在中枢神经系统。(C)2001爱思唯尔科学爱尔兰有限公司保留所有权利。
For better understanding of the behavior of water molecules in the animal brain, changes in magnetic resonance water proton relaxation processes were studied in the rat during maturation. Midbrains of male Wistar rats were removed at various time points ranging from 2 to 70 days after birth. Changes in relaxation time (water proton longitudinal relaxation time by the inversion recovery, and water proton transverse relaxation time by the spin echo and the Carr-Purcell-Meiboom-Gill pulse sequence (CPMG)) and water content were then determined for various stages of brain development. During maturation both water proton longitudinal relaxation time and water proton transverse relaxation time values decreased and this finding paralleled the decline in water content. Using the CPMG pulse sequence, the transverse relaxation time values were observed to separate into two components after 21 days. Morphologically, the most prominent change at the matured stage of midbrain development in the rat is myelination. Water proton relaxation time, which can be estimated using the CPMG pulse sequence, showed a close correlation with myelination in the central nervous system. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.