Developmental expression of transforming growth factors alpha and beta in mouse fetus
Developmental expression of transforming growth factors alpha and beta in mouse fetus
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DOI：
10.1128/mcb.8.8.3415-3422.1988
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发表时间：
1988-08
影响因子：
5.3
通讯作者：
Josiah N. Wilcox;R. Derynck
中科院分区：
文献类型：
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作者：
Josiah N. Wilcox;R. Derynck
通过原位杂交评价小鼠胚胎发育过程中转化生长因子α（TGF-α）和TGF-β 1的mRNA表达。在9天和10天的胎儿中检测到TGF-α mRNA，但在较大的胎儿中不存在。在胎盘、耳泡、口腔、咽囊、第一和第二鳃弓和发育中的肾脏中发现了含TGF-α mRNA的细胞。TGF-β 1的mRNA存在于血岛和毛细血管的造血细胞中，并且在肝脏中，因为它在第10天开始萌芽并作为造血器官发挥功能。
Expression of mRNA for transforming growth factor alpha (TGF-alpha) and TGF-beta 1 during the fetal development of mice was evaluated by in situ hybridization. TGF-alpha mRNA was detected in 9- and 10-day fetuses but was absent in older fetuses. TGF-alpha mRNA-containing cells were found in the placenta, otic vesicle, oral cavity, pharyngeal pouch, first and second branchial arches, and developing kidneys. mRNA for TGF-beta 1 was present in hematopoietic cells of blood islands and capillaries and in the liver as it began to bud off on day 10 and function as a hematopoietic organ.