Defining Prescription Drug Misuse: A Naturalistic Evaluation of National Survey on Drug Use and Health Data From 2012-2014 to 2015-2017.
Defining Prescription Drug Misuse: A Naturalistic Evaluation of National Survey on Drug Use and Health Data From 2012-2014 to 2015-2017.
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定义处方药滥用：对 2012-2014 年至 2015-2017 年全国药物使用和健康数据调查的自然评价。
DOI：
10.1097/adm.0000000000001115
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发表时间：
2023
影响因子：
5.5
通讯作者：
Fitzmaurice,GarrettM
中科院分区：
文献类型：
--
作者：
McHugh,RKathryn;Votaw,VictoriaR;McCarthy,MeganD;Bichon,JulietteA;Bailey,AllenJ;Fitzmaurice,GarrettM
目的预见性药物滥用是一个重大的公共卫生问题。随着研究的发展，滥用的定义随着时间的推移而变化，但这种差异的含义尚未被系统地研究。这项研究的目的是利用大规模人口调查中对产品数据管理的测量方法的变化，以确定其对这种行为的患病率和相关性的影响。方法比较全国药物使用与健康调查的数据，在产品数据管理的定义从限制来源和使用动机更改为包括任何非处方指示的滥用之前和之后的数据。建立了为期三年的队列，代表了有限的定义(2012-2014)和广义的定义(2015-2017)。结果分段Logistic回归模型显示，所考察的3种药物(阿片类药物、镇静剂和镇静剂)的DM患病率显著增加。尽管根据药物类型的不同，差异的大小有所不同，但更广泛的定义通常与年龄较大、医疗保险患病率较高以及滥用自己的处方的几率较高有关。心理健康指标有一定程度的恶化，但结果显示其他临床或物质使用差异不大。结论处方药物滥用定义对滥用发生率有实质性影响，并对人群特征有一定影响。需要进一步的研究，以了解基于科学或公共卫生问题或兴趣来衡量这种行为的最佳策略。
ObjectivesPrescription drug misuse (PDM) is a significant public health problem. As research has evolved, the definitions of misuse have varied over time, yet the implications of this variability have not been systematically studied. The objective of this study was to leverage a change in the measurement of PDM in a large population survey to identify its impact on the prevalence and correlates of this behavior.MethodsData from the National Survey on Drug Use and Health were compared before and after a change in the definition of PDM from one that restricted the source and motive for use to one that captured any misuse other than directed by a prescriber. Three-year cohorts were constructed, representing a restricted definition of PDM (2012–2014) and a broad definition of PDM (2015–2017).ResultsSegmented logistic regression models indicated a significant increase in PDM prevalence for all 3 drug types examined (opioids, tranquilizers, and sedatives). Although the magnitude of differences varied somewhat based on drug type, the broader definition was generally associated with older age, higher prevalence of health insurance, and higher odds of misusing one's own prescription. Some worsening of mental health indicators was observed, but results indicated few other clinical or substance use differences.ConclusionsDefinitions of prescription drug misuse have a substantial impact on the prevalence of misuse and some impact on the characteristics of the population. Further research is needed to understand the optimal strategy for measuring this behavior, based on the scientific or public health question or interest.