Constructing Implantable SrTiO3:Yb,Ho Nanofibers for NIR-Triggered and Optically Monitored Chemotherapy
Constructing Implantable SrTiO3:Yb,Ho Nanofibers for NIR-Triggered and Optically Monitored Chemotherapy
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构建用于近红外触发和光学监测化疗的植入式 SrTiO3:Yb,Ho 纳米纤维
DOI：
10.1002/chem.201604956
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Han Gaorong
中科院分区：
文献类型：
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作者：
Fu Yike;Fang Chao;Ren Zhaohui;Xu Gang;Li Xiang;Han Gaorong
光响应和光致发光（PL）药物递送平台由于其在生物成像和操纵释放动力学方面的独特特性，在个性化肿瘤化疗方面取得了令人瞩目的进展。本文合成了可植入的Yb 3+和Ho 3+共掺杂的钛酸锶（SrTiO 3：Yb，Ho）纳米纤维，并在其表面用聚丙烯酸（PAA）分子修饰。初步体外试验证实，这种可植入纤维网具有良好的细胞相容性。PAA表面装饰提高了抗癌药物（阿霉素（DOX））的负载能力，并有效地防止了在中性水环境中的令人生畏的爆发释放。由于PAA和DOX分子之间的静电键，低pH微环境和NIR（λ=808 nm）照射均诱导显著加速DOX释放，从而增强局部癌细胞杀伤作用。 此外，由于荧光共振能量转移（FRET）效应，SrTiO 3：Yb，Ho-PAA纤维的绿色发射与红色发射的比率（I545/I655）有效地响应于DOX释放进程和剂量。这种独特的特性使得能够及时地对交付进度进行光学监控。这些SrTiO 3：Yb，Ho-PAA纳米纤维具有精确的双触发和DOX释放的光学监测功能，有望在未来作为个性化化疗的新型植入式药物输送平台。
Light‐responsive and photoluminescent (PL) drug‐delivery platforms have sparked fascinating advancements in personalized tumor chemotherapy due to their unique characteristics in biological imaging and manipulated release kinetics. Herein, implantable Yb3+and Ho3+co‐doped strontium titanate (SrTiO3:Yb,Ho) nanofibers were synthesized and decorated on the surface with polyacrylic acid (PAA) molecules. The preliminary in vitro assay confirmed that this implantable fibrous mesh presented sound cytocompatibility. The PAA surface decoration improved the loading capacity of an anticancer drug (doxorubicin (DOX)) and effectively prevented a daunting burst release in a neutral aqueous environment. Owing to the electrostatic bond between PAA and DOX molecules, low‐pH microenvironments and NIR (λ=808 nm) irradiation both induced significantly accelerated DOX release and consequently enhanced the local cancer‐cell‐killing effect. Additionally, the ratio of green‐to‐red emission (I545/I655) from the SrTiO3:Yb,Ho‐PAA fibers responded effectively to the DOX release progress and dosage due to a fluorescence resonance energy transfer (FRET) effect. This unique characteristic enabled optical monitoring of the delivery progress in a timely manner. These SrTiO3:Yb,Ho‐PAA nanofibers, with precise dual‐triggering and optical monitoring of DOX release, are expected to serve as a new implantable drug delivery platform for personalized chemotherapy in the future.