Biomarkers of oxidative damage and inflammation in Alzheimer's disease.
Biomarkers of oxidative damage and inflammation in Alzheimer's disease.
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DOI：
10.2217/bmm.09.89
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发表时间：
2010-02
影响因子：
2.2
通讯作者：
Montine TJ
中科院分区：
文献类型：
--
作者：
Galasko D;Montine TJ
氧化损伤和炎症是阿尔茨海默病（AD）脑病理的重要特征。氧化损伤可以在膜（脂质过氧化）、蛋白质（亚硝基化和其他翻译后变化）和核酸中发现。炎症变化包括小胶质细胞和星形胶质细胞的激活，促炎细胞因子水平升高。并非所有这些变化都是AD所特有的，也会发生在其他神经退行性疾病中。氧化应激和炎症都是AD的潜在治疗靶点，生物标志物可以帮助识别和监测AD患者的关键通路。本文综述了与氧化应激和炎症相关的脑脊液生物标志物的研究进展、系统性（血液或尿液）生物标志物在这一领域存在的问题和缺陷，以及未来的研究方向和应用。
Oxidative damage and inflammation are important features of the brain pathology of Alzheimer’s disease (AD). Oxidative damage can be found in membranes (lipid peroxidation), proteins (nitrosylation and other post-translational changes) and nucleic acids. Inflammatory changes include activation of microglia and astrocytes, with increased levels of proinflammatory cytokines. Not all of these changes are specific to AD, and occur in other neurodegenerative disorders. Both oxidative stress and inflammation are potential therapeutic targets in AD, and biomarkers could help to identify and monitor key pathways in patients with AD. This article summarizes progress in developing cerebrospinal fluid biomarkers related to oxidative stress and inflammation, problems and pitfalls related to systemic (blood- or urine-based) biomarkers in this area, and future research directions and applications.