ON THE ORIGIN OF ENZYMATIC SPECIES
ON THE ORIGIN OF ENZYMATIC SPECIES
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DOI：
10.1016/0968-0004(93)90091-z
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发表时间：
1993-10-01
影响因子：
13.8
通讯作者：
KOZARICH, JW
中科院分区：
文献类型：
--
作者：
PETSKO, GA;KENYON, GL;KOZARICH, JW
酶催化功能的多样性是显著的，特别是当人们考虑到祖先的生命形式必须从一个小得多的蛋白质集合开始时。在这篇文章中，我们讨论了扁桃酸途径的演变假单胞菌作为一个例子，如何催化多样性可能已经演变。我们认为，现有的酶催化的化学需要完成的转化被招募，然后通过特异性结合的演变。
The diversity of enzyme catalytic function is remarkable, particularly when one considers that ancestral life forms must have started with a much smaller ensemble of proteins. In this article, we discuss the evolution of the mandelate pathway in pseudomonads as an example of how catalytic diversity may have evolved. We suggest that existing enzymes that catalyse the chemistry needed to accomplish a transformation were recruited, followed by the evolution of specific binding.