7 to 12 Hz activity in rat gustatory cortex reflects disengagement from a fluid self-administration task
7 to 12 Hz activity in rat gustatory cortex reflects disengagement from a fluid self-administration task
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DOI：
10.1152/jn.01035.2004
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发表时间：
2005-05-01
影响因子：
2.5
通讯作者：
Katz, DB
中科院分区：
文献类型：
--
作者：
Fontanini, A;Katz, DB
7 至 12 Hz 节律是在许多大鼠新皮质区域记录的高压振荡现象，很大程度上类似于啮齿动物和人类体感 mu 节律。对这种模式的功能意义的任何解释的核心是与其相关的行为背景的分析。关于 mu 功能的许多争论主要依赖于它与安静不动的联系，人们普遍认为它代表了一种面向环境的状态或一种孤立的状态。在这份报告中，我们描述了 7 至 12 Hz 节奏与更复杂的行为环境之间的关系，在这种关系中我们能够将任务导向与脱离联系分开。我们训练头部受限、限水的大鼠执行定时液体自我管理任务的简单变体，同时记录味觉皮层（GC）的局部场电位。老鼠经历了两种在杠杆按压机制的基础上明显区分的行为状态：一种是任务导向的状态，另一种是反映脱离任务的状态。并发 GC 神经记录显示 7 至 12 Hz 范围内的双边相干振荡仅与后一种状态相关。与已发表的体感皮层 mu 节律记录一致，当大鼠准备按下杠杆时，这些节律发作被内源性猝灭；这种对节律发作的抑制通过液体输送和消耗持续存在，这清楚地表明GC节律与味觉处理本身无关。通过显示 7 至 12 Hz 节律与脱离任务之间的直接关系，这些数据提供了强有力且新颖的证据，证明大鼠的这种味觉节律与退出实验意外事件有关。
The 7 to 12 Hz rhythm is a high-voltage oscillatory phenomenon recorded in many rat neocortical regions, largely analogous to the rodent and human somatosensory mu rhythm. Central to any interpretation of the functional significance of this pattern is the analysis of the behavioral context associated with it. Much of the debate on the function of mu, variously believed to represent either an environment-oriented or - isolated state, has relied primarily on its association with quiet immobility. In this report, we describe the relationship between the 7 to 12 Hz rhythm and a more complex behavioral setting, in which we were able to dissociated task orientation from disengagement. We trained head-restrained, water-restricted rats to perform a simple variant of a timed fluid self-administration task, while recording local field potentials from gustatory cortex ( GC). Rats progressed through two behavioral states that were clearly distinguishable on the basis of lever-pressing regimes: a task-oriented state and a second state that reflected disengagement from the task. Concurrent GC neural recordings revealed bilaterally coherent oscillations in the 7 to 12 Hz range associated solely with the latter state. Consistent with published recordings of mu rhythm from somatosensory cortex, these rhythmic episodes were endogenously quenched when the rats prepared to lever-press; this inhibition of rhythmic episodes lasted through fluid delivery and consumption, making it clear that GC rhythms are not related to gustatory processing itself. By showing a direct relationship between the 7 to 12 Hz rhythm and disengagement from a task, these data provide strong and novel evidence that this gustatory rhythm in rats is associated with withdrawal from experimental contingencies.