Historical perspectives and the future of adverse reactions associated with haemopoietic stem cells cryopreserved with dimethyl sulfoxide
Historical perspectives and the future of adverse reactions associated with haemopoietic stem cells cryopreserved with dimethyl sulfoxide
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DOI：
10.1007/s10561-011-9248-2
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发表时间：
2012-06-01
影响因子：
1.5
通讯作者：
Hrubisko, Mikulas
中科院分区：
文献类型：
--
作者：
Cox, Michael A.;Kastrup, Jens;Hrubisko, Mikulas
对已发表文献的回顾性审查确定了数百例不良反应（例如，G.恶心、寒战、心律失常、神经症状和呼吸停止）。这些反应的发生通常被认为是常见的，因为大多数反应是短暂的，而少数患者可能需要临床治疗。本探索性研究是对历史数据和严重不良反应通知预期的整理。概要信息的发展，相关的欧洲指令，二甲基亚砜和保存和管理的顺序阶段的一些技术方面。
A retrospective review of the published literature identified several hundred adverse reactions (e. g. nausea, chills, cardiac arrhythmias, neurological symptoms and respiratory arrest) associated with the transplantation of stem cells cryopreserved with dimethyl sulfoxide. The occurrences of these are generally accepted as commonplace, as the majority of reactions are transient, whilst a few patients may require clinical treatment. This exploratory study is a collation of the historical data and the expectations for the notification of serious adverse reactions. Outline information is presented on the development of related European Directives, some technical aspects of dimethyl sulfoxide and the sequential stages of preservation and administration.