Temporal development of Drosophila embryos is highly robust across a wide temperature range
Temporal development of Drosophila embryos is highly robust across a wide temperature range
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DOI：
10.1098/rsif.2018.0304
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发表时间：
2018-07-01
影响因子：
3.9
通讯作者：
Saunders, Timothy E.
中科院分区：
文献类型：
--
作者：
Chong, Jeronica;Amourda, Christopher;Saunders, Timothy E.
发展是一个在空间和时间上精确协调的过程。空间精度已被量化在一些发展系统，这些数据已经大大有助于我们的理解，例如，形态梯度的解释。然而，相对较少的定量分析已经进行了时间和时间的协调发展。在这里，我们使用果蝇来探索在生理正常温度下胚胎发育的时间稳健性。我们发现，在广泛的温度范围内的三个果蝇物种的调查，发展是非常精确的时间。然而，我们发现温度依赖性的发育事件的时间。一个简单的模型，包括历史依赖可以解释发展的时间轨迹。有趣的是，历史依赖性是温度特异性的，在不同温度下具有有效的负反馈或正反馈。我们还发现，胚胎在胚胎发生过程中对温度的变化具有惊人的鲁棒性。我们进一步确定热带和温带物种之间的差异，可能是由于不同的机制调节时间的发展，取决于当地的环境。我们的数据表明，果蝇胚胎发育在很宽的温度范围内都是暂时稳定的。这种鲁棒性显示了有趣的物种特异性差异，这表明果蝇物种之间对温度波动的敏感性不同。
Development is a process precisely coordinated in both space and time. Spatial precision has been quantified in a number of developmental systems, and such data have contributed significantly to our understanding of, for example, morphogen gradient interpretation. However, comparatively little quantitative analysis has been performed on timing and temporal coordination during development. Here, we use Drosophila to explore the temporal robustness of embryonic development within physiologically normal temperatures. We find that development is temporally very precise across a wide range of temperatures in the three Drosophila species investigated. However, we find temperature dependence in the timing of developmental events. A simple model incorporating history dependence can explain the developmental temporal trajectories. Interestingly, history dependence is temperature-specific, with either effective negative or positive feedback at different temperatures. We also find that embryos are surprisingly robust to shifting temperatures during embryogenesis. We further identify differences between tropical and temperate species, potentially due to different mechanisms regulating temporal development that depend on the local environment. Our data show that Drosophila embryonic development is temporally robust across a wide range of temperatures. This robustness shows interesting species-specific differences that are suggestive of different sensitivity to temperature fluctuations between Drosophila species.