DAP-kinase as a target for drug design in cancer and diseases associated with accelerated cell death
DAP-kinase as a target for drug design in cancer and diseases associated with accelerated cell death
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DOI：
10.1016/j.semcancer.2004.04.008
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发表时间：
2004-08-01
影响因子：
14.5
通讯作者：
Kimchi, A
中科院分区：
文献类型：
--
作者：
Bialik, S;Kimchi, A
失调的细胞死亡可导致细胞的过度、不适当的清除，或损伤或恶性细胞的清除不足，这与许多疾病有关。在这里，我们讨论了一个重要的细胞死亡分子调节剂，dap激酶（DAM），它提出了一个有希望的治疗干预靶点。我们将对这种钙调控的促进细胞死亡的丝氨酸/苏氨酸激酶进行结构-功能分析，并将重点放在其调节可能影响临床相关细胞死亡过程的特定疾病模型上。(C) 2004 Elsevier Ltd.版权所有。
Misregulated cell death, which can result in either the excessive, inappropriate elimination of cells, or in the insufficient removal of damaged or malignant cells, has been associated with numerous diseases. Here we discuss an important molecular regulator of cell death, DAP-kinase (DAM), which presents a promising target for therapeutic intervention. A structure-functional analysis of this calcium-regulated Ser/Thr kinase which promotes cell death will be presented, and emphasis will be placed on particular disease models in which its modulation might affect clinically-relevant cell death processes. (C) 2004 Elsevier Ltd. All rights reserved.